MAB2659

antibody from R&D Systems

Targeting: NECTIN4 LNIR, nectin-4, PRR4, PVRL4

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

MAB2659

Provider

R&D Systems

Product name

Human Nectin-4 Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from hybridoma culture supernatant. Detects human Nectin-4 in direct ELISAs and Western blots. In direct ELISAs and Western blots, does not cross-react with recombinant human Nectin-1, -2, -3, or recombinant mouse Nectin-4.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

Q96NY8


Isotype

IgG

Antibody clone number

337516

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17.

Buchanan PC, Boylan KLM, Walcheck B, Heinze R, Geller MA, Argenta PA, Skubitz APN
The Journal of biological chemistry 2017 Apr 14;292(15):6339-6351

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A role for PVRL4-driven cell-cell interactions in tumorigenesis.

Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJ
eLife 2013 Apr 30;2:e00358

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Nectin 4 overexpression in ovarian cancer tissues and serum: potential role as a serum biomarker.

Derycke MS, Pambuccian SE, Gilks CB, Kalloger SE, Ghidouche A, Lopez M, Bliss RL, Geller MA, Argenta PA, Harrington KM, Skubitz AP
American journal of clinical pathology 2010 Nov;134(5):835-45