324001

antibody from BioLegend
Targeting: CDCP1 CD318, SIMA135
Provider product page for 324001
Flow cytometry

Antibody data

Product number
324001 - Provider product page
Provider
BioLegend
Product name
Purified anti-human CD318 (CDCP1)
Antibody type
Monoclonal
Antigen
NIH-3T3 cells transfected with human CDCP1
Description
The CUB1 antibody recognizes CD318 also known as CDCP1, CUB domain containing protein 1, and SIMA135. CD318 is a transmembrane protein containing three CUB domains with a predicted molecular weight of approximately 93 kD. Alternately spliced isoforms have also been reported. CD318 is a marker for immature hematopoietic progenitor cell subsets and is also expressed in mesenchymal stem cells and neural progenitor cell populations. This marker is also widely distributed in a variety of cell types including keratinocytes, skeletal muscle, colon, kidney, lung, small intestine. CD318 is overexpressed in colon and lung tumors and expression level has been shown to correlate with metastatic ability of carcinomas. CD318 interacts with plasminogen, matriptase, and c-Src (phosphorylates residue Y734). The function of CD318 is not well understood although it is thought to be involved in early hematopoiesis. The CUB1 antibody has been shown to be useful for flow cytometry.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C.
CDCP1 protein structure - 324001 shown in red.