NBP2-47800AF700

antibody from Novus Biologicals

Targeting: LAIR1 CD305

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NBP2-47800AF700

Provider

Novus Biologicals

Product name

Mouse Monoclonal LAIR1 Antibody

Antibody type

Monoclonal

Description

Protein A or G purified. Recognizes a single protein of 40kDa, identified as the CD305 (LAIR1). It is an inhibitory receptor, expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. This MAb is expressed on CD34 positive hematopoietic progenitors. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. This MAb is identical to LAIR-1, based on the fact that it not only precipitated a protein of 40kDa but it also binds specifically to LAIR-1 cDNA transfected COS7 cells as well as recognizes LAIR-1 fusion protein in ELISA. LAIR-1 expresses on hematopoietic progenitor, implicating its role in the regulation of hematopoiesis at early stage.

Reactivity

Human

Host

Mouse

Conjugate

Near infrared dye

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark.