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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 328645 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#328645, RRID:AB_2566114
- Product name
- PE/Dazzle™ 594 anti-human CD107a (LAMP-1)
- Antibody type
- Monoclonal
- Antigen
- Human adult adherent peripheral blood cells
- Description
- CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.
- Reactivity
- Human, Porcine
- Host
- Mouse
- Conjugate
- Red dye
- Antibody clone number
- H4A3
- Vial size
- 25 tests
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Thrombin-activated human peripheral blood platelets were stained with CD107a (clone H4A3) PE/Dazzle™ 594 (filled histogram) or mouse IgG1, κ PE/Dazzle™ 594 isotype control (open histogram).
