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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Validations
- Flow cytometry [1]
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- Product number
- 328618 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#328618, RRID:AB_11147955
- Product name
- PE/Cy7 anti-human CD107a (LAMP-1)
- Antibody type
- Monoclonal
- Antigen
- Human adult adherent peripheral blood cells
- Description
- CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. The mature CD107a is heavily glycosylated from a 40 kD core protein. It is expressed by activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. This molecule is located on the luminal side of lysosomes and has been suggested to play a role in the protection of lysosomes membrane from lysosomal hydrolases. Upon activation, CD107a is transferred to the cell membrane surface. It plays a role in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Infrared dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
Hook2 is involved in the morphogenesis of the primary cilium.
Watanabe A, Tatematsu M, Saeki K, Shibata S, Shime H, Yoshimura A, Obuse C, Seya T, Matsumoto M
The Journal of biological chemistry 2011 Mar 25;286(12):10702-11
The Journal of biological chemistry 2011 Mar 25;286(12):10702-11
Hook2 is involved in the morphogenesis of the primary cilium.
Baron Gaillard CL, Pallesi-Pocachard E, Massey-Harroche D, Richard F, Arsanto JP, Chauvin JP, Lecine P, Krämer H, Borg JP, Le Bivic A
Molecular biology of the cell 2011 Dec;22(23):4549-62
Molecular biology of the cell 2011 Dec;22(23):4549-62
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Thrombin-activated human peripheral blood platelets were stained with CD107a (clone H4A3) PE/Cy7 (filled histogram) or mouse IgG1, κ PE/Cy7 isotype control (open histogram).
- Conjugate
- Near infrared dye
