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LearnFAB195P-025
antibody from R&D Systems
Targeting: CCR6
BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- FAB195P-025 - Provider product page
- Provider
- R&D Systems
- Product name
- Human CCR6 PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human CCR6. Stains human CCR6 transfectants but not the parental cell line in flow cytometry. Does not cross-react with transfectants expressing human CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CXCR1, CXCR2, CXCR3, CXCR4, or STRL33.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
P51684- Isotype
- IgG
- Antibody clone number
- 53103
- Vial size
- 25 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire.
Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion.
Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors.
Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.
Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells.
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection.
Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes.
CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1.
Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells.
Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals.
Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation.
Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients.
Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis.
Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation.
Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge.
Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
Dimova T, Brouwer M, Gosselin F, Tassignon J, Leo O, Donner C, Marchant A, Vermijlen D
Proceedings of the National Academy of Sciences of the United States of America 2015 Feb 10;112(6):E556-65
Proceedings of the National Academy of Sciences of the United States of America 2015 Feb 10;112(6):E556-65
Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion.
Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo LV, Marti LC
PloS one 2014;9(9):e106673
PloS one 2014;9(9):e106673
Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors.
Cerdeira AS, Rajakumar A, Royle CM, Lo A, Husain Z, Thadhani RI, Sukhatme VP, Karumanchi SA, Kopcow HD
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 15;190(8):3939-48
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 15;190(8):3939-48
Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.
Badr G, Lefevre EA, Mohany M
PloS one 2011;6(9):e23741
PloS one 2011;6(9):e23741
Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells.
Dusseaux M, Martin E, Serriari N, Péguillet I, Premel V, Louis D, Milder M, Le Bourhis L, Soudais C, Treiner E, Lantz O
Blood 2011 Jan 27;117(4):1250-9
Blood 2011 Jan 27;117(4):1250-9
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 15;184(6):2886-98
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 15;184(6):2886-98
AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection.
Campillo-Gimenez L, Cumont MC, Fay M, Kared H, Monceaux V, Diop O, Müller-Trutwin M, Hurtrel B, Lévy Y, Zaunders J, Dy M, Leite-de-Moraes MC, Elbim C, Estaquier J
Journal of immunology (Baltimore, Md. : 1950) 2010 Jan 15;184(2):984-92
Journal of immunology (Baltimore, Md. : 1950) 2010 Jan 15;184(2):984-92
Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes.
Pène J, Chevalier S, Preisser L, Vénéreau E, Guilleux MH, Ghannam S, Molès JP, Danger Y, Ravon E, Lesaux S, Yssel H, Gascan H
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 1;180(11):7423-30
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 1;180(11):7423-30
CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1.
Nonomura C, Kikuchi J, Kiyokawa N, Ozaki H, Mitsunaga K, Ando H, Kanamori A, Kannagi R, Fujimoto J, Muroi K, Furukawa Y, Nakamura M
Cancer research 2008 Feb 1;68(3):790-9
Cancer research 2008 Feb 1;68(3):790-9
Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells.
Spadaro M, Caorsi C, Ceruti P, Varadhachary A, Forni G, Pericle F, Giovarelli M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 Aug;22(8):2747-57
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 Aug;22(8):2747-57
Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals.
Moir S, Ho J, Malaspina A, Wang W, DiPoto AC, O'Shea MA, Roby G, Kottilil S, Arthos J, Proschan MA, Chun TW, Fauci AS
The Journal of experimental medicine 2008 Aug 4;205(8):1797-805
The Journal of experimental medicine 2008 Aug 4;205(8):1797-805
Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation.
Maru SV, Holloway KA, Flynn G, Lancashire CL, Loughlin AJ, Male DK, Romero IA
Journal of neuroimmunology 2008 Aug 13;199(1-2):35-45
Journal of neuroimmunology 2008 Aug 13;199(1-2):35-45
Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients.
Winter D, Moser J, Kriehuber E, Wiesner C, Knobler R, Trautinger F, Bombosi P, Stingl G, Petzelbauer P, Rot A, Maurer D
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):4272-82
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):4272-82
Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis.
Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, Gurrieri C, Trentin L, Zambello R, Calabrese F, Cassatella MA, Semenzato G, Agostini C
Journal of leukocyte biology 2007 Oct;82(4):946-55
Journal of leukocyte biology 2007 Oct;82(4):946-55
Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation.
Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, Zamarchi R, Tamamura H, Fujii N, Semenzato G, Chieco-Bianchi L, Amadori A
Blood 2005 Feb 1;105(3):931-9
Blood 2005 Feb 1;105(3):931-9
Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge.
Liu LY, Jarjour NN, Busse WW, Kelly EA
The Journal of allergy and clinical immunology 2003 Sep;112(3):556-62
The Journal of allergy and clinical immunology 2003 Sep;112(3):556-62
Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A
Journal of leukocyte biology 2003 May;73(5):584-90
Journal of leukocyte biology 2003 May;73(5):584-90
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of CCR6 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD19 APC-conjugated Monoclonal Antibody (Catalog # FAB4867A) and either (A) Mouse Anti-Human CCR6 PE-conjugated Monoclonal Antibody (Catalog # FAB195P) or (B) Mouse IgG2B Phycoerythrin Isotype Control (Catalog # IC0041P). View our protocol for Staining Membrane-associated Proteins.
