353431

antibody from BioLegend
Targeting: CCR6 BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22
Provider product page for 353431

Antibody data

Product number
353431 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#353431, RRID:AB_2566273
Product name
APC/Cy7 anti-human CD196 (CCR6)
Antibody type
Monoclonal
Antigen
CCR6-transfected cells
Description
CCR6, also known as CD196, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.
Reactivity
Human
Host
Mouse
Antibody clone number
G034E3
Vial size
25 tests
Storage
2°C-8°C
Handling
Ambient RT
CCR6 protein structure - 353431 shown in red.