NBP2-47759-0.1mg

antibody from Novus Biologicals

Targeting: CCR5 CC-CKR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22

Immunocytochemistry

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Validation data

Product number: NBP2-47759-0.1mg - Provider product page
Provider: Novus Biologicals
Product name: Mouse Monoclonal CCR5 Antibody
Antibody type: Monoclonal
Description: Protein A or G purified. Reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
Reactivity: Human
Host: Mouse
Isotype: IgG
Vial size: 0.1 mg
Concentration: 1.0 mg/ml
Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

CCR5 protein structure - NBP2-47759-0.1mg shown in red.