Antibody data

Product number
47-0792-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD79a Monoclonal Antibody (HM47), APC-eFluor™ 780, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The monoclonal antibody HM47 recognizes the cytoplasmic domain of CD79a, also known as mb-1. CD79a is a 47 kDa membrane glycoprotein that associates with CD79b to form the heterodimeric B cell receptor (BCR). This receptor is responsible for B cell signaling, resulting in activation, apoptosis or anergy. Expression of CD79a is found throughout development from the earliest pre-B cell to plasma cells. CD79 is expressed on B cell neoplasms and some non-B cell malignancies such as AML. Unlike other antibodies that can be masked in B cell neoplastic cells, HM47 is a reliable antibody for recognizing CD79a and, as such, is a good marker for B cells. Because several variants of CD79a exist, the exact location of the epitope may differ slightly. Nevertheless, in humans thie epitope is typically amino acids 208-222.
Antibody clone number
HM47
Concentration
5 µL/Test
CD79A protein structure - 47-0792-42 shown in red.