AF3039

antibody from R&D Systems

Targeting: IFNAR1 IFNAR, IFRC

Western blot (Data presented on provider website)

Blocking/Neutralizing (Supportive data in Antibodypedia)

Antibody Data

Product number

AF3039

Provider

R&D Systems

Product name

Mouse IFN-alpha/beta R1 Antibody

Antibody type

Polyclonal

Description

Immunogen affinity purified. Detects mouse IFN-alpha/beta R1 in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant mouse (rm) IFN-alpha/beta R2, rmIFN-gamma R1, and rmIFN-gamma R2 is observed.

Reactivity

Mouse

Host

Goat

Conjugate

Unconjugated

Antigen sequence

P33896


Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Toll-like receptor (TLR)2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cells.

Vanhoutte F, Paget C, Breuilh L, Fontaine J, Vendeville C, Goriely S, Ryffel B, Faveeuw C, Trottein F
Immunology letters 2008 Feb 15;116(1):86-94

Blocking/Neutralizing

Supportive validation

Submitted by

R&D Systems (provider)

Main image

Experimental details

Limitin Inhibition of EMCV-induced Cytopathy and Neutralization by Mouse IFN-alpha/beta R1 Antibody. Recombinant Mouse Limitin (Catalog # 1535-LM) reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the L-929 mouse fibroblast cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recombinant Mouse Limitin (30 pg/mL) is neutralized (green line) by increasing concentrations of Mouse IFN-alpha/beta R1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3039). The ND₅₀ is typically 1-4 µg/mL.