Tissue expression
Cell line expression

HIKESHI

gene product
C11orf73, HSPC138, HSPC179, OPI10 
This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016]
More gene data

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175 antibodies from 25 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
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antibodies-online
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2 antibodies
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2 antibodies
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Abgent
1 antibody
Acris Antibodies GmbH
1 antibody
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8 antibodies
LifeSpan BioSciences, Inc.
29 antibodies
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2 antibodies
Novus Biologicals
4 antibodies
Atlas Antibodies
2 antibodies
Abnova Corporation
2 antibodies
MyBioSource
3 antibodies
GeneTex
1 antibody
United States Biological
13 antibodies
Affinity Biosciences
1 antibody
Leading Biology
1 antibody
MilliporeSigma / Merck KGaA
1 antibody
Abbexa
6 antibodies
Creative Diagnostics
1 antibody
Creative Biolabs
1 antibody