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- Antibody Data
- Antigen structure
- References [99]
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- Product number
- 05-636 - Provider product page
- Provider
- EMD Millipore
- Proper citation
- Millipore Cat#05-636, RRID:AB_309864
- Product name
- Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301
- Antibody type
- Monoclonal
- Antigen
- peptide (C-KATQA[pS]QEY) corresponding to amino acids 134-142 of human histone H2A.X
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- JBW301
- Vial size
- 200 µg
- Storage
- Maintain for 1 year at 2 to 8°C from date of shipment. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Submitted references PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.
PARP inhibition sensitizes to low dose-rate radiation TMPRSS2-ERG fusion gene-expressing and PTEN-deficient prostate cancer cells.
Loss of WSTF results in spontaneous fluctuations of heterochromatin formation and resolution, combined with substantial changes to gene expression.
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.
Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state.
APLF promotes the assembly and activity of non-homologous end joining protein complexes.
High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapy.
The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme.
DNA replication fading as proliferating cells advance in their commitment to terminal differentiation.
Localization and regulation of murine Esco2 during male and female meiosis.
Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanism.
Genotoxic stress modulates CDC25C phosphatase alternative splicing in human breast cancer cell lines.
The role of ATM and 53BP1 as predictive markers in cervical cancer.
RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells.
The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult.
Proteasome inhibition and ROS generation by 4-nerolidylcatechol induces melanoma cell death.
Lack of a p21waf1/cip -dependent G1/S checkpoint in neural stem and progenitor cells after DNA damage in vivo.
Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations.
Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma.
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.
Rad9B responds to nucleolar stress through ATR and JNK signalling, and delays the G1-S transition.
The activation of DNA damage detection and repair responses in cleavage-stage rat embryos by a damaged paternal genome.
Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.
Toxicity and genotoxicity of nano-SiO2 on human epithelial intestinal HT-29 cell line.
Role of SUMO modification of human PCNA at stalled replication fork.
ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy.
HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells.
A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest.
Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma.
Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.
Dynamic chromatin environment of key lytic cycle regulatory regions of the Epstein-Barr virus genome.
The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep?
Tumor suppressor TAp73 gene specifically responds to deregulated E2F activity in human normal fibroblasts.
BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair.
Metformin reduces endogenous reactive oxygen species and associated DNA damage.
Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication.
Probing the telomere damage response.
Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects.
Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response.
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells.
Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair.
MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells.
Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal.
Double-strand break-induced transcriptional silencing is associated with loss of tri-methylation at H3K4.
Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells.
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.
Protein-protein interactions occur between p53 phosphoforms and ATM and 53BP1 at sites of exogenous DNA damage.
Proteomic profiling revealed the functional networks associated with mitotic catastrophe of HepG2 hepatoma cells induced by 6-bromine-5-hydroxy-4-methoxybenzaldehyde.
Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks.
Role for cohesin in the formation of a heterochromatic domain at fission yeast subtelomeres.
DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription.
The ATM kinase signaling induced by the low-energy β-particles emitted by (33)P is essential for the suppression of chromosome aberrations and is greater than that induced by the energetic β-particles emitted by (32)P.
Residual DNA and chromosomal damage in ex vivo irradiated blood lymphocytes correlated with late normal tissue response to breast radiotherapy.
Differential expression of the ADAMs in developing chicken retina.
The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress.
Impact of induced pluripotent stem cells on the study of central nervous system disease.
Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2.
Biological in-vivo measurement of dose distribution in patients' lymphocytes by gamma-H2AX immunofluorescence staining: 3D conformal- vs. step-and-shoot IMRT of the prostate gland.
Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS).
The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination.
Specific inhibition of NF-Y subunits triggers different cell proliferation defects.
Isolation of mouse mesenchymal stem cells with normal ploidy from bone marrows by reducing oxidative stress in combination with extracellular matrix.
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.
Snm1B/Apollo functions in the Fanconi anemia pathway in response to DNA interstrand crosslinks.
UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway.
PARP-3 and APLF function together to accelerate nonhomologous end-joining.
Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks.
Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53.
MDC1 cleavage by caspase-3: a novel mechanism for inactivating the DNA damage response during apoptosis.
MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression.
DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor.
Stage-specific modulation of cortical neuronal development by Mmu-miR-134.
Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.
Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.
Blockade of the NFκB pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo.
DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary.
Replication stress induces 53BP1-containing OPT domains in G1 cells.
HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair.
Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells.
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.
5-Aza-2'-deoxycytidine sensitizes busulfan-resistant myeloid leukemia cells by regulating expression of genes involved in cell cycle checkpoint and apoptosis.
DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression.
Prostate-specific natural health products (dietary supplements) radiosensitize normal prostate cells.
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage.
Telomere maintenance and DNA damage responses during lung carcinogenesis.
Parp1-XRCC1 and the repair of DNA double strand breaks in mouse round spermatids.
The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint.
Evidence for DNA damage checkpoint activation in barrett esophagus.
Molecular mechanism underlying the synergistic interaction between trifluorothymidine and the epidermal growth factor receptor inhibitor erlotinib in human colorectal cancer cell lines.
Unsuitability of lymphoblastoid cell lines as surrogate of cryopreserved isolated lymphocytes for the analysis of DNA double-strand break repair activity.
Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks.
Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase.
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.
Paternal exposure to cyclophosphamide affects the progression of sperm chromatin decondensation and activates a DNA damage response in the prepronuclear rat zygote.
The NER proteins XPC and CSB, but not ERCC1, regulate the sensitivity to the novel DNA binder S23906: implications for recognition and repair of antitumor alkylators.
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.
Radiation Sensitivity and Tumor Susceptibility in ATM Phospho-Mutant ATF2 Mice.
RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX.
Rulten SL, Rotheray A, Green RL, Grundy GJ, Moore DA, Gómez-Herreros F, Hafezparast M, Caldecott KW
Nucleic acids research 2014 Jan;42(1):307-14
Nucleic acids research 2014 Jan;42(1):307-14
PARP inhibition sensitizes to low dose-rate radiation TMPRSS2-ERG fusion gene-expressing and PTEN-deficient prostate cancer cells.
Chatterjee P, Choudhary GS, Sharma A, Singh K, Heston WD, Ciezki J, Klein EA, Almasan A
PloS one 2013;8(4):e60408
PloS one 2013;8(4):e60408
Loss of WSTF results in spontaneous fluctuations of heterochromatin formation and resolution, combined with substantial changes to gene expression.
Culver-Cochran AE, Chadwick BP
BMC genomics 2013 Oct 29;14:740
BMC genomics 2013 Oct 29;14:740
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.
Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, Botuyan MV, Mer G, Greenberg RA
Nature structural & molecular biology 2013 Mar;20(3):317-25
Nature structural & molecular biology 2013 Mar;20(3):317-25
Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state.
González F, Georgieva D, Vanoli F, Shi ZD, Stadtfeld M, Ludwig T, Jasin M, Huangfu D
Cell reports 2013 Mar 28;3(3):651-60
Cell reports 2013 Mar 28;3(3):651-60
APLF promotes the assembly and activity of non-homologous end joining protein complexes.
Grundy GJ, Rulten SL, Zeng Z, Arribas-Bosacoma R, Iles N, Manley K, Oliver A, Caldecott KW
The EMBO journal 2013 Jan 9;32(1):112-25
The EMBO journal 2013 Jan 9;32(1):112-25
High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapy.
Magnussen GI, Holm R, Emilsen E, Rosnes AK, Slipicevic A, Flørenes VA
PloS one 2012;7(6):e38254
PloS one 2012;7(6):e38254
The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme.
Yang D, Tan M, Wang G, Sun Y
PloS one 2012;7(3):e34079
PloS one 2012;7(3):e34079
DNA replication fading as proliferating cells advance in their commitment to terminal differentiation.
Estefanía MM, Ganier O, Hernández P, Schvartzman JB, Mechali M, Krimer DB
Scientific reports 2012;2:279
Scientific reports 2012;2:279
Localization and regulation of murine Esco2 during male and female meiosis.
Evans EB, Hogarth C, Evanoff RM, Mitchell D, Small C, Griswold MD
Biology of reproduction 2012 Sep;87(3):61
Biology of reproduction 2012 Sep;87(3):61
Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanism.
Beishline K, Kelly CM, Olofsson BA, Koduri S, Emrich J, Greenberg RA, Azizkhan-Clifford J
Molecular and cellular biology 2012 Sep;32(18):3790-9
Molecular and cellular biology 2012 Sep;32(18):3790-9
Genotoxic stress modulates CDC25C phosphatase alternative splicing in human breast cancer cell lines.
Albert H, Battaglia E, Monteiro C, Bagrel D
Molecular oncology 2012 Oct;6(5):542-52
Molecular oncology 2012 Oct;6(5):542-52
The role of ATM and 53BP1 as predictive markers in cervical cancer.
Roossink F, Wieringa HW, Noordhuis MG, ten Hoor KA, Kok M, Slagter-Menkema L, Hollema H, de Bock GH, Pras E, de Vries EG, de Jong S, van der Zee AG, Schuuring E, Wisman GB, van Vugt MA
International journal of cancer. Journal international du cancer 2012 Nov 1;131(9):2056-66
International journal of cancer. Journal international du cancer 2012 Nov 1;131(9):2056-66
RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells.
Oestergaard VH, Pentzold C, Pedersen RT, Iosif S, Alpi A, Bekker-Jensen S, Mailand N, Lisby M
DNA repair 2012 Nov 1;11(11):892-905
DNA repair 2012 Nov 1;11(11):892-905
The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult.
Tsolou A, Nelson G, Trachana V, Chondrogianni N, Saretzki G, von Zglinicki T, Gonos ES
IUBMB life 2012 May;64(5):432-42
IUBMB life 2012 May;64(5):432-42
Proteasome inhibition and ROS generation by 4-nerolidylcatechol induces melanoma cell death.
Brohem CA, Massaro RR, Tiago M, Marinho CE, Jasiulionis MG, de Almeida RL, Rivelli DP, Albuquerque RC, de Oliveira TF, de Melo Loureiro AP, Okada S, Soengas MS, de Moraes Barros SB, Maria-Engler SS
Pigment cell & melanoma research 2012 May;25(3):354-69
Pigment cell & melanoma research 2012 May;25(3):354-69
Lack of a p21waf1/cip -dependent G1/S checkpoint in neural stem and progenitor cells after DNA damage in vivo.
Roque T, Haton C, Etienne O, Chicheportiche A, Rousseau L, Martin L, Mouthon MA, Boussin FD
Stem cells (Dayton, Ohio) 2012 Mar;30(3):537-47
Stem cells (Dayton, Ohio) 2012 Mar;30(3):537-47
Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations.
Jacquemin V, Rieunier G, Jacob S, Bellanger D, d'Enghien CD, Laugé A, Stoppa-Lyonnet D, Stern MH
European journal of human genetics : EJHG 2012 Mar;20(3):305-12
European journal of human genetics : EJHG 2012 Mar;20(3):305-12
Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma.
Koduru S, Wong E, Strowig T, Sundaram R, Zhang L, Strout MP, Flavell RA, Schatz DG, Dhodapkar KM, Dhodapkar MV
Blood 2012 Mar 8;119(10):2302-9
Blood 2012 Mar 8;119(10):2302-9
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.
Brough R, Bajrami I, Vatcheva R, Natrajan R, Reis-Filho JS, Lord CJ, Ashworth A
The EMBO journal 2012 Mar 7;31(5):1160-76
The EMBO journal 2012 Mar 7;31(5):1160-76
Rad9B responds to nucleolar stress through ATR and JNK signalling, and delays the G1-S transition.
Pérez-Castro AJ, Freire R
Journal of cell science 2012 Mar 1;125(Pt 5):1152-64
Journal of cell science 2012 Mar 1;125(Pt 5):1152-64
The activation of DNA damage detection and repair responses in cleavage-stage rat embryos by a damaged paternal genome.
Grenier L, Robaire B, Hales BF
Toxicological sciences : an official journal of the Society of Toxicology 2012 Jun;127(2):555-66
Toxicological sciences : an official journal of the Society of Toxicology 2012 Jun;127(2):555-66
Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.
Parikh N, Shuck RL, Nguyen TA, Herron A, Donehower LA
Molecular cancer research : MCR 2012 Jun;10(6):845-55
Molecular cancer research : MCR 2012 Jun;10(6):845-55
Toxicity and genotoxicity of nano-SiO2 on human epithelial intestinal HT-29 cell line.
Sergent JA, Paget V, Chevillard S
The Annals of occupational hygiene 2012 Jul;56(5):622-30
The Annals of occupational hygiene 2012 Jul;56(5):622-30
Role of SUMO modification of human PCNA at stalled replication fork.
Gali H, Juhasz S, Morocz M, Hajdu I, Fatyol K, Szukacsov V, Burkovics P, Haracska L
Nucleic acids research 2012 Jul;40(13):6049-59
Nucleic acids research 2012 Jul;40(13):6049-59
ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy.
Rodríguez-Vargas JM, Ruiz-Magaña MJ, Ruiz-Ruiz C, Majuelos-Melguizo J, Peralta-Leal A, Rodríguez MI, Muñoz-Gámez JA, de Almodóvar MR, Siles E, Rivas AL, Jäättela M, Oliver FJ
Cell research 2012 Jul;22(7):1181-98
Cell research 2012 Jul;22(7):1181-98
HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells.
Peixoto P, Castronovo V, Matheus N, Polese C, Peulen O, Gonzalez A, Boxus M, Verdin E, Thiry M, Dequiedt F, Mottet D
Cell death and differentiation 2012 Jul;19(7):1239-52
Cell death and differentiation 2012 Jul;19(7):1239-52
A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest.
Feng Z, Zhang J
Nucleic acids research 2012 Jan;40(2):726-38
Nucleic acids research 2012 Jan;40(2):726-38
Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma.
Modi BG, Neustadter J, Binda E, Lewis J, Filler RB, Roberts SJ, Kwong BY, Reddy S, Overton JD, Galan A, Tigelaar R, Cai L, Fu P, Shlomchik M, Kaplan DH, Hayday A, Girardi M
Science (New York, N.Y.) 2012 Jan 6;335(6064):104-8
Science (New York, N.Y.) 2012 Jan 6;335(6064):104-8
Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.
Wei D, Li H, Yu J, Sebolt JT, Zhao L, Lawrence TS, Smith PG, Morgan MA, Sun Y
Cancer research 2012 Jan 1;72(1):282-93
Cancer research 2012 Jan 1;72(1):282-93
Dynamic chromatin environment of key lytic cycle regulatory regions of the Epstein-Barr virus genome.
Ramasubramanyan S, Osborn K, Flower K, Sinclair AJ
Journal of virology 2012 Feb;86(3):1809-19
Journal of virology 2012 Feb;86(3):1809-19
The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep?
Goehe RW, Di X, Sharma K, Bristol ML, Henderson SC, Valerie K, Rodier F, Davalos AR, Gewirtz DA
The Journal of pharmacology and experimental therapeutics 2012 Dec;343(3):763-78
The Journal of pharmacology and experimental therapeutics 2012 Dec;343(3):763-78
Tumor suppressor TAp73 gene specifically responds to deregulated E2F activity in human normal fibroblasts.
Ozono E, Komori H, Iwanaga R, Tanaka T, Sakae T, Kitamura H, Yamaoka S, Ohtani K
Genes to cells : devoted to molecular & cellular mechanisms 2012 Aug;17(8):660-72
Genes to cells : devoted to molecular & cellular mechanisms 2012 Aug;17(8):660-72
BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair.
Chapman JR, Sossick AJ, Boulton SJ, Jackson SP
Journal of cell science 2012 Aug 1;125(Pt 15):3529-34
Journal of cell science 2012 Aug 1;125(Pt 15):3529-34
Metformin reduces endogenous reactive oxygen species and associated DNA damage.
Algire C, Moiseeva O, Deschênes-Simard X, Amrein L, Petruccelli L, Birman E, Viollet B, Ferbeyre G, Pollak MN
Cancer prevention research (Philadelphia, Pa.) 2012 Apr;5(4):536-43
Cancer prevention research (Philadelphia, Pa.) 2012 Apr;5(4):536-43
Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication.
Punchihewa C, Inoue A, Hishiki A, Fujikawa Y, Connelly M, Evison B, Shao Y, Heath R, Kuraoka I, Rodrigues P, Hashimoto H, Kawanishi M, Sato M, Yagi T, Fujii N
The Journal of biological chemistry 2012 Apr 20;287(17):14289-300
The Journal of biological chemistry 2012 Apr 20;287(17):14289-300
Probing the telomere damage response.
Rai R, Chang S
Methods in molecular biology (Clifton, N.J.) 2011;735:145-50
Methods in molecular biology (Clifton, N.J.) 2011;735:145-50
Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects.
Romero Y, Meikar O, Papaioannou MD, Conne B, Grey C, Weier M, Pralong F, De Massy B, Kaessmann H, Vassalli JD, Kotaja N, Nef S
PloS one 2011;6(10):e25241
PloS one 2011;6(10):e25241
Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response.
Fradet-Turcotte A, Bergeron-Labrecque F, Moody CA, Lehoux M, Laimins LA, Archambault J
Journal of virology 2011 Sep;85(17):8996-9012
Journal of virology 2011 Sep;85(17):8996-9012
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells.
Toller IM, Neelsen KJ, Steger M, Hartung ML, Hottiger MO, Stucki M, Kalali B, Gerhard M, Sartori AA, Lopes M, Müller A
Proceedings of the National Academy of Sciences of the United States of America 2011 Sep 6;108(36):14944-9
Proceedings of the National Academy of Sciences of the United States of America 2011 Sep 6;108(36):14944-9
Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair.
Peterson SE, Li Y, Chait BT, Gottesman ME, Baer R, Gautier J
The Journal of cell biology 2011 Sep 5;194(5):705-20
The Journal of cell biology 2011 Sep 5;194(5):705-20
MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells.
Bridges KA, Hirai H, Buser CA, Brooks C, Liu H, Buchholz TA, Molkentine JM, Mason KA, Meyn RE
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Sep 1;17(17):5638-48
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Sep 1;17(17):5638-48
Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal.
Wang J, Geesman GJ, Hostikka SL, Atallah M, Blackwell B, Lee E, Cook PJ, Pasaniuc B, Shariat G, Halperin E, Dobke M, Rosenfeld MG, Jordan IK, Lunyak VV
Cell cycle (Georgetown, Tex.) 2011 Sep 1;10(17):3016-30
Cell cycle (Georgetown, Tex.) 2011 Sep 1;10(17):3016-30
Double-strand break-induced transcriptional silencing is associated with loss of tri-methylation at H3K4.
Seiler DM, Rouquette J, Schmid VJ, Strickfaden H, Ottmann C, Drexler GA, Mazurek B, Greubel C, Hable V, Dollinger G, Cremer T, Friedl AA
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2011 Oct;19(7):883-99
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2011 Oct;19(7):883-99
Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells.
Knobel PA, Kotov IN, Felley-Bosco E, Stahel RA, Marti TM
Neoplasia (New York, N.Y.) 2011 Oct;13(10):961-70
Neoplasia (New York, N.Y.) 2011 Oct;13(10):961-70
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.
Zhang W, Peng G, Lin SY, Zhang P
The Journal of biological chemistry 2011 Oct 14;286(41):35899-905
The Journal of biological chemistry 2011 Oct 14;286(41):35899-905
Protein-protein interactions occur between p53 phosphoforms and ATM and 53BP1 at sites of exogenous DNA damage.
Al Rashid ST, Harding SM, Law C, Coackley C, Bristow RG
Radiation research 2011 May;175(5):588-98
Radiation research 2011 May;175(5):588-98
Proteomic profiling revealed the functional networks associated with mitotic catastrophe of HepG2 hepatoma cells induced by 6-bromine-5-hydroxy-4-methoxybenzaldehyde.
Zhang B, Huang B, Guan H, Zhang SM, Xu QZ, He XP, Liu XD, Wang Y, Shang ZF, Zhou PK
Toxicology and applied pharmacology 2011 May 1;252(3):307-17
Toxicology and applied pharmacology 2011 May 1;252(3):307-17
Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks.
Williamson LM, Lees-Miller SP
Carcinogenesis 2011 Mar;32(3):279-85
Carcinogenesis 2011 Mar;32(3):279-85
Role for cohesin in the formation of a heterochromatic domain at fission yeast subtelomeres.
Dheur S, Saupe SJ, Genier S, Vazquez S, Javerzat JP
Molecular and cellular biology 2011 Mar;31(5):1088-97
Molecular and cellular biology 2011 Mar;31(5):1088-97
DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription.
Zamudio NM, Scott HS, Wolski K, Lo CY, Law C, Leong D, Kinkel SA, Chong S, Jolley D, Smyth GK, de Kretser D, Whitelaw E, O'Bryan MK
PloS one 2011 Mar 31;6(3):e18276
PloS one 2011 Mar 31;6(3):e18276
The ATM kinase signaling induced by the low-energy β-particles emitted by (33)P is essential for the suppression of chromosome aberrations and is greater than that induced by the energetic β-particles emitted by (32)P.
White JS, Yue N, Hu J, Bakkenist CJ
Mutation research 2011 Mar 15;708(1-2):28-36
Mutation research 2011 Mar 15;708(1-2):28-36
Residual DNA and chromosomal damage in ex vivo irradiated blood lymphocytes correlated with late normal tissue response to breast radiotherapy.
Chua ML, Somaiah N, A'Hern R, Davies S, Gothard L, Yarnold J, Rothkamm K
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011 Jun;99(3):362-6
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011 Jun;99(3):362-6
Differential expression of the ADAMs in developing chicken retina.
Yan X, Lin J, Rolfs A, Luo J
Development, growth & differentiation 2011 Jun;53(5):726-39
Development, growth & differentiation 2011 Jun;53(5):726-39
The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress.
Kamranvar SA, Masucci MG
Leukemia 2011 Jun;25(6):1017-25
Leukemia 2011 Jun;25(6):1017-25
Impact of induced pluripotent stem cells on the study of central nervous system disease.
Cundiff PE, Anderson SA
Current opinion in genetics & development 2011 Jun;21(3):354-61
Current opinion in genetics & development 2011 Jun;21(3):354-61
Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2.
Pernicová Z, Slabáková E, Kharaishvili G, Bouchal J, Král M, Kunická Z, Machala M, Kozubík A, Souček K
Neoplasia (New York, N.Y.) 2011 Jun;13(6):526-36
Neoplasia (New York, N.Y.) 2011 Jun;13(6):526-36
Biological in-vivo measurement of dose distribution in patients' lymphocytes by gamma-H2AX immunofluorescence staining: 3D conformal- vs. step-and-shoot IMRT of the prostate gland.
Zwicker F, Swartman B, Sterzing F, Major G, Weber KJ, Huber PE, Thieke C, Debus J, Herfarth K
Radiation oncology (London, England) 2011 Jun 7;6:62
Radiation oncology (London, England) 2011 Jun 7;6:62
Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS).
Ohanna M, Giuliano S, Bonet C, Imbert V, Hofman V, Zangari J, Bille K, Robert C, Bressac-de Paillerets B, Hofman P, Rocchi S, Peyron JF, Lacour JP, Ballotti R, Bertolotto C
Genes & development 2011 Jun 15;25(12):1245-61
Genes & development 2011 Jun 15;25(12):1245-61
The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination.
Cherubini G, Naim V, Caruso P, Burla R, Bogliolo M, Cundari E, Benihoud K, Saggio I, Rosselli F
Nucleic acids research 2011 Jul;39(13):5459-73
Nucleic acids research 2011 Jul;39(13):5459-73
Specific inhibition of NF-Y subunits triggers different cell proliferation defects.
Benatti P, Dolfini D, Viganò A, Ravo M, Weisz A, Imbriano C
Nucleic acids research 2011 Jul;39(13):5356-68
Nucleic acids research 2011 Jul;39(13):5356-68
Isolation of mouse mesenchymal stem cells with normal ploidy from bone marrows by reducing oxidative stress in combination with extracellular matrix.
Fan G, Wen L, Li M, Li C, Luo B, Wang F, Zhou L, Liu L
BMC cell biology 2011 Jul 6;12:30
BMC cell biology 2011 Jul 6;12:30
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.
Mendoza-Maldonado R, Faoro V, Bajpai S, Berti M, Odreman F, Vindigni M, Ius T, Ghasemian A, Bonin S, Skrap M, Stanta G, Vindigni A
Molecular cancer 2011 Jul 13;10:83
Molecular cancer 2011 Jul 13;10:83
Snm1B/Apollo functions in the Fanconi anemia pathway in response to DNA interstrand crosslinks.
Mason JM, Sekiguchi JM
Human molecular genetics 2011 Jul 1;20(13):2549-59
Human molecular genetics 2011 Jul 1;20(13):2549-59
UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway.
Pinato S, Gatti M, Scandiuzzi C, Confalonieri S, Penengo L
Molecular and cellular biology 2011 Jan;31(1):118-26
Molecular and cellular biology 2011 Jan;31(1):118-26
PARP-3 and APLF function together to accelerate nonhomologous end-joining.
Rulten SL, Fisher AE, Robert I, Zuma MC, Rouleau M, Ju L, Poirier G, Reina-San-Martin B, Caldecott KW
Molecular cell 2011 Jan 7;41(1):33-45
Molecular cell 2011 Jan 7;41(1):33-45
Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks.
Liberti SE, Andersen SD, Wang J, May A, Miron S, Perderiset M, Keijzers G, Nielsen FC, Charbonnier JB, Bohr VA, Rasmussen LJ
DNA repair 2011 Jan 2;10(1):73-86
DNA repair 2011 Jan 2;10(1):73-86
Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53.
He X, Ni Y, Wang Y, Romigh T, Eng C
Human molecular genetics 2011 Jan 1;20(1):80-9
Human molecular genetics 2011 Jan 1;20(1):80-9
MDC1 cleavage by caspase-3: a novel mechanism for inactivating the DNA damage response during apoptosis.
Solier S, Pommier Y
Cancer research 2011 Feb 1;71(3):906-13
Cancer research 2011 Feb 1;71(3):906-13
MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression.
Wang Y, Huang JW, Li M, Cavenee WK, Mitchell PS, Zhou X, Tewari M, Furnari FB, Taniguchi T
Molecular cancer research : MCR 2011 Aug;9(8):1100-11
Molecular cancer research : MCR 2011 Aug;9(8):1100-11
DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor.
Guo L, Liu X, Jiang Y, Nishikawa K, Plunkett W
Molecular pharmacology 2011 Aug;80(2):321-7
Molecular pharmacology 2011 Aug;80(2):321-7
Stage-specific modulation of cortical neuronal development by Mmu-miR-134.
Gaughwin P, Ciesla M, Yang H, Lim B, Brundin P
Cerebral cortex (New York, N.Y. : 1991) 2011 Aug;21(8):1857-69
Cerebral cortex (New York, N.Y. : 1991) 2011 Aug;21(8):1857-69
Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.
Sooryakumar D, Dexheimer TS, Teicher BA, Pommier Y
Molecular cancer therapeutics 2011 Aug;10(8):1490-9
Molecular cancer therapeutics 2011 Aug;10(8):1490-9
Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.
Domínguez-Kelly R, Martín Y, Koundrioukoff S, Tanenbaum ME, Smits VA, Medema RH, Debatisse M, Freire R
The Journal of cell biology 2011 Aug 22;194(4):567-79
The Journal of cell biology 2011 Aug 22;194(4):567-79
Blockade of the NFκB pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo.
Nogueira L, Ruiz-Ontañon P, Vazquez-Barquero A, Lafarga M, Berciano MT, Aldaz B, Grande L, Casafont I, Segura V, Robles EF, Suarez D, Garcia LF, Martinez-Climent JA, Fernandez-Luna JL
Oncogene 2011 Aug 11;30(32):3537-48
Oncogene 2011 Aug 11;30(32):3537-48
DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary.
Krentz AD, Murphy MW, Sarver AL, Griswold MD, Bardwell VJ, Zarkower D
Developmental biology 2011 Aug 1;356(1):63-70
Developmental biology 2011 Aug 1;356(1):63-70
Replication stress induces 53BP1-containing OPT domains in G1 cells.
Harrigan JA, Belotserkovskaya R, Coates J, Dimitrova DS, Polo SE, Bradshaw CR, Fraser P, Jackson SP
The Journal of cell biology 2011 Apr 4;193(1):97-108
The Journal of cell biology 2011 Apr 4;193(1):97-108
HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair.
Baldeyron C, Soria G, Roche D, Cook AJ, Almouzni G
The Journal of cell biology 2011 Apr 4;193(1):81-95
The Journal of cell biology 2011 Apr 4;193(1):81-95
Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells.
Winsel S, Sommer A, Eschenbrenner J, Mittelstaedt K, Klar U, Hammer S, Hoffmann J
PloS one 2011 Apr 29;6(4):e19273
PloS one 2011 Apr 29;6(4):e19273
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.
Dedes KJ, Wetterskog D, Mendes-Pereira AM, Natrajan R, Lambros MB, Geyer FC, Vatcheva R, Savage K, Mackay A, Lord CJ, Ashworth A, Reis-Filho JS
Science translational medicine 2010 Oct 13;2(53):53ra75
Science translational medicine 2010 Oct 13;2(53):53ra75
5-Aza-2'-deoxycytidine sensitizes busulfan-resistant myeloid leukemia cells by regulating expression of genes involved in cell cycle checkpoint and apoptosis.
Valdez BC, Li Y, Murray D, Corn P, Champlin RE, Andersson BS
Leukemia research 2010 Mar;34(3):364-72
Leukemia research 2010 Mar;34(3):364-72
DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression.
An J, Huang YC, Xu QZ, Zhou LJ, Shang ZF, Huang B, Wang Y, Liu XD, Wu DC, Zhou PK
BMC molecular biology 2010 Mar 6;11:18
BMC molecular biology 2010 Mar 6;11:18
Prostate-specific natural health products (dietary supplements) radiosensitize normal prostate cells.
Hasan Y, Schoenherr D, Martinez AA, Wilson GD, Marples B
International journal of radiation oncology, biology, physics 2010 Mar 1;76(3):896-904
International journal of radiation oncology, biology, physics 2010 Mar 1;76(3):896-904
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
Abreu E, Aritonovska E, Reichenbach P, Cristofari G, Culp B, Terns RM, Lingner J, Terns MP
Molecular and cellular biology 2010 Jun;30(12):2971-82
Molecular and cellular biology 2010 Jun;30(12):2971-82
Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage.
Abella N, Brun S, Calvo M, Tapia O, Weber JD, Berciano MT, Lafarga M, Bachs O, Agell N
Traffic (Copenhagen, Denmark) 2010 Jun;11(6):743-55
Traffic (Copenhagen, Denmark) 2010 Jun;11(6):743-55
Telomere maintenance and DNA damage responses during lung carcinogenesis.
Lantuejoul S, Raynaud C, Salameire D, Gazzeri S, Moro-Sibilot D, Soria JC, Brambilla C, Brambilla E
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jun 1;16(11):2979-88
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jun 1;16(11):2979-88
Parp1-XRCC1 and the repair of DNA double strand breaks in mouse round spermatids.
Ahmed EA, de Boer P, Philippens ME, Kal HB, de Rooij DG
Mutation research 2010 Jan 5;683(1-2):84-90
Mutation research 2010 Jan 5;683(1-2):84-90
The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint.
LaGory EL, Sitailo LA, Denning MF
The Journal of biological chemistry 2010 Jan 15;285(3):1879-87
The Journal of biological chemistry 2010 Jan 15;285(3):1879-87
Evidence for DNA damage checkpoint activation in barrett esophagus.
von Holzen U, Chen T, Boquoi A, Richter JE, Falk GW, Klein-Szanto AJ, Cooper H, Litwin S, Weinberg DS, Enders GH
Translational oncology 2010 Feb;3(1):33-42
Translational oncology 2010 Feb;3(1):33-42
Molecular mechanism underlying the synergistic interaction between trifluorothymidine and the epidermal growth factor receptor inhibitor erlotinib in human colorectal cancer cell lines.
Bijnsdorp IV, Kruyt FA, Fukushima M, Smid K, Gokoel S, Peters GJ
Cancer science 2010 Feb;101(2):440-7
Cancer science 2010 Feb;101(2):440-7
Unsuitability of lymphoblastoid cell lines as surrogate of cryopreserved isolated lymphocytes for the analysis of DNA double-strand break repair activity.
Zijno A, Porcedda P, Saini F, Allione A, Garofalo B, Marcon F, Guarrera S, Turinetto V, Minieri V, Funaro A, Crebelli R, Giachino C, Matullo G
Mutation research 2010 Feb 3;684(1-2):98-105
Mutation research 2010 Feb 3;684(1-2):98-105
Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks.
Barash H, R Gross E, Edrei Y, Ella E, Israel A, Cohen I, Corchia N, Ben-Moshe T, Pappo O, Pikarsky E, Goldenberg D, Shiloh Y, Galun E, Abramovitch R
Proceedings of the National Academy of Sciences of the United States of America 2010 Feb 2;107(5):2207-12
Proceedings of the National Academy of Sciences of the United States of America 2010 Feb 2;107(5):2207-12
Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase.
Niida H, Katsuno Y, Sengoku M, Shimada M, Yukawa M, Ikura M, Ikura T, Kohno K, Shima H, Suzuki H, Tashiro S, Nakanishi M
Genes & development 2010 Feb 15;24(4):333-8
Genes & development 2010 Feb 15;24(4):333-8
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.
Tsai KJ, Yang CH, Fang YH, Cho KH, Chien WL, Wang WT, Wu TW, Lin CP, Fu WM, Shen CK
The Journal of experimental medicine 2010 Aug 2;207(8):1661-73
The Journal of experimental medicine 2010 Aug 2;207(8):1661-73
Paternal exposure to cyclophosphamide affects the progression of sperm chromatin decondensation and activates a DNA damage response in the prepronuclear rat zygote.
Grenier L, Robaire B, Hales BF
Biology of reproduction 2010 Aug 1;83(2):195-204
Biology of reproduction 2010 Aug 1;83(2):195-204
The NER proteins XPC and CSB, but not ERCC1, regulate the sensitivity to the novel DNA binder S23906: implications for recognition and repair of antitumor alkylators.
Rocca CJ, Poindessous V, Soares DG, Ouadrani KE, Sarasin A, Guérin E, de Gramont A, Henriques JA, Escargueil AE, Larsen AK
Biochemical pharmacology 2010 Aug 1;80(3):335-43
Biochemical pharmacology 2010 Aug 1;80(3):335-43
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.
Macůrek L, Lindqvist A, Voets O, Kool J, Vos HR, Medema RH
Oncogene 2010 Apr 15;29(15):2281-91
Oncogene 2010 Apr 15;29(15):2281-91
Radiation Sensitivity and Tumor Susceptibility in ATM Phospho-Mutant ATF2 Mice.
Li S, Ezhevsky S, Dewing A, Cato MH, Scortegagna M, Bhoumik A, Breitwieser W, Braddock D, Eroshkin A, Qi J, Chen M, Kim JY, Jones S, Jones N, Rickert R, Ronai ZA
Genes & cancer 2010 Apr 1;1(4):316-330
Genes & cancer 2010 Apr 1;1(4):316-330
RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX.
Pinato S, Scandiuzzi C, Arnaudo N, Citterio E, Gaudino G, Penengo L
BMC molecular biology 2009 Jun 5;10:55
BMC molecular biology 2009 Jun 5;10:55
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Supportive validation
- Submitted by
- EMD Millipore (provider)
- Main image
- Experimental details
- WB: Staurosporine-treated (lane 1), and untreated (lane 2) Jurkat cell lysates were probed with Anti-phospho-Histone H2A.X (Ser139), clone JBW301 (0.05µg/ml).
- Validation comment
- WB
