orb18139

antibody from Biorbyt
Targeting: PRKCG MGC57564, PKCC, PKCG, PKCĪ³, SCA14
Provider product page for orb18139

Antibody data

Product number
orb18139 - Provider product page
Provider
Biorbyt
Proper citation
Biorbyt Cat#orb18139, RRID:AB_10748446
Product name
PRKCG antibody
Antibody type
Polyclonal
Description
Rabbit Polyclonal to PRKCG. The gamma isotype of protein kinase C (PKC gamma) is a member of the classical PKC (cPKC) subfamily which is activated by Ca(2+) and diacylglycerol in the presence of phosphatidylserine. Physiologically, PKC gamma is activated by a mechanism coupled with receptor-mediated breakdown of inositol phospholipid as other cPKC isotypes such as PKC alpha and PKC beta. PKC gamma is expressed solely in the brain and spinal cord and its localization is restricted to neurons, while PKC alpha and PKC beta are expressed in many tissues in addition to the brain. Within the brain, PKC gamma is the most abundant in the cerebellum, hippocampus and cerebral cortex, where the existence of neuronal plasticity has been demonstrated. PKC gamma gene is mutated in spinocerebellar ataxia type 14 (SCA14). Verbeek et al. (2005) point out the specific alterations in mutant PKC gamma function that could lead to the selective neuronal degeneration of SCA14.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Vial size
100 μg
Concentration
Lyophilized Powder
Storage
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
PRKCG protein structure - orb18139 shown in red.