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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Validations
- Flow cytometry [1]
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- Product number
- 324614 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#324614, RRID:AB_11218991
- Product name
- FITC anti-human CD203c (E-NPP3)
- Antibody type
- Monoclonal
- Antigen
- HEK-293 cells transfected with human E-NPP3
- Description
- CD203c, a transmembrane protein and a member of the ectoenzyme family, is involved in the hydrolysis of extracellular oligonucleotides, nucleoside phosphates, and NAD (possesses ATPase and ATP pyrophosphatase activity). The molecular weight of CD203c was observed to be 130 and 150 kD under reducing conditions and 270 kD under non-reducing conditions. CD203c is expressed on basophils and mast cells, and is highly expressed on activated basophils. Secretory glands in endometrium and glioma cells are also positive. CD203c is a multifunctional ectoenzyme involved in the clearance of extracellular nucleotides whose substrates include nucleoside triphosphates, nucleoside diphosphates, cAMP, and NAD.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Green dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy.
Basophils and the T helper 2 environment can promote the development of lupus nephritis.
Gernez Y, Tirouvanziam R, Yu G, Ghosn EE, Reshamwala N, Nguyen T, Tsai M, Galli SJ, Herzenberg LA, Herzenberg LA, Nadeau KC
International archives of allergy and immunology 2011;154(4):318-27
International archives of allergy and immunology 2011;154(4):318-27
Basophils and the T helper 2 environment can promote the development of lupus nephritis.
Charles N, Hardwick D, Daugas E, Illei GG, Rivera J
Nature medicine 2010 Jun;16(6):701-7
Nature medicine 2010 Jun;16(6):701-7
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Overnight cultured human peripheral blood mononuclear cells were stained with anti-human IgE APC and CD203c (clone NP4D6) FITC (top), or mouse IgG1, κ FITC isotype control (bottom).
- Conjugate
- Green dye
