ABIN196947

antibody from antibodies-online

Targeting: CDKN1B KIP1, P27KIP1

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN196947

Provider

antibodies-online

Product name

anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (pThr187) antibody

Antibody type

Polyclonal

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human, Mouse

Host

Rabbit

Epitope

pThr187

Vial size

50 μL

Storage

-20°C

Handling

Avoid repeated freezing and thawing.

References

Submitted references

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis.

Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM
Molecular biology of the cell 2003 Jan;14(1):201-13

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Helicobacter pylori increases proteasome-mediated degradation of p27(kip1) in gastric epithelial cells.

Eguchi H, Herschenhous N, Kuzushita N, Moss SF
Cancer research 2003 Aug 1;63(15):4739-46

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Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.

Fujita N, Sato S, Katayama K, Tsuruo T
The Journal of biological chemistry 2002 Aug 9;277(32):28706-13

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Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.

Ishida N, Kitagawa M, Hatakeyama S, Nakayama K
The Journal of biological chemistry 2000 Aug 18;275(33):25146-54