347501

antibody from BioLegend
Targeting: TNFSF11 CD254, ODF, OPGL, RANKL, TRANCE
Provider product page for 347501

Antibody data

Product number
347501 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#347501, RRID:AB_2044062
Product name
Purified anti-human CD254 (TRANCE, RANKL)
Antibody type
Monoclonal
Antigen
RANKL-transfected L cells
Description
Human RANKL (receptor activator of NF-kB ligand), also known as TRANCE (TNF-related activation-induced cytokine receptor) and OPGL (Osteoprotegerin ligand), and CD254, is a type II transmembrane protein in theTNF superfamily. It has two forms - a membrane-anchored protein and a secreted protein. Its extracellular domain is related to TRAIL, FasL, and TNF. TRANCE is expressed on osteoclasts and activated T cells. It has been implicated in the regulation of T cell and dendritic cell interactions. RANKL plays an important role in osteoclast differentiation and bone resorption. TRANCE activates JNK and NF-κB and induces the expression of IL-1, IL-6, IL-12, and IL-15 in dendritic cells.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4 °C.
TNFSF11 protein structure - 347501 shown in red.