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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Flow cytometry [1]
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- Product number
- 501414 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#501414, RRID:AB_493319
- Product name
- Alexa Fluor® 647 anti-human IL-10 [JES3-9D7]
- Antibody type
- Monoclonal
- Antigen
- COS - expressed, recombinant human IL-10
- Description
- IL-10 was originally described as Cytokine Synthesis Inhibitory Factor (CSIF) by virtue of its ability to inhibit cytokine production by Th1 clones. IL-10 shares over 80% sequence homology with the Epstein-Barr virus protein BCRFI. The biological activities of IL-10 include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed type hypersensitivity response, and stimulation of the Th2 cell response, which results in elevated antibody production. The JES3-9D7 antibody reacts with human and viral interleukin-10 (IL-10).
- Reactivity
- Human, Simian
- Host
- Rat
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Glucocorticosteroids modify Langerhans cells to produce TGF-β and expand regulatory T cells.
Stary G, Klein I, Bauer W, Koszik F, Reininger B, Kohlhofer S, Gruber K, Skvara H, Jung T, Stingl G
Journal of immunology (Baltimore, Md. : 1950) 2011 Jan 1;186(1):103-12
Journal of immunology (Baltimore, Md. : 1950) 2011 Jan 1;186(1):103-12
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- Experimental details
- LPS-stimulated (overnight) human peripheral blood monocytes surface stained with with CD14 (M5E2) PE and intracellularly stained with JES3-9D7 Alexa Fluor® 647
- Conjugate
- Red dye
