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- Antibody Data
- Antigen structure
- References [5]
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- Product number
- ABIN967755 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (AA 1-217) antibody
- Antibody type
- Monoclonal
- Antigen
- Rat GRB2
- Description
- Purified from tissue culture supernatant or ascites by affinity chromatography.
- Reactivity
- Rat
- Host
- Mouse
- Epitope
- AA 1-217
- Isotype
- IgG
- Antibody clone number
- C595(NCRC48)
- Vial size
- 150 μg
- Concentration
- 250 μg/ml
- Storage
- -20°C
Submitted references Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis.
Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction.
Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.
Association of Ash/Grb-2 with dynamin through the Src homology 3 domain.
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
Saucier C, Papavasiliou V, Palazzo A, Naujokas MA, Kremer R, Park M
Oncogene 2002 Mar 14;21(12):1800-11
Oncogene 2002 Mar 14;21(12):1800-11
Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction.
Elowe S, Holland SJ, Kulkarni S, Pawson T
Molecular and cellular biology 2001 Nov;21(21):7429-41
Molecular and cellular biology 2001 Nov;21(21):7429-41
Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.
Zeng L, Sachdev P, Yan L, Chan JL, Trenkle T, McClelland M, Welsh J, Wang LH
Molecular and cellular biology 2000 Dec;20(24):9212-24
Molecular and cellular biology 2000 Dec;20(24):9212-24
Association of Ash/Grb-2 with dynamin through the Src homology 3 domain.
Miki H, Miura K, Matuoka K, Nakata T, Hirokawa N, Orita S, Kaibuchi K, Takai Y, Takenawa T
The Journal of biological chemistry 1994 Feb 25;269(8):5489-92
The Journal of biological chemistry 1994 Feb 25;269(8):5489-92
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J
Cell 1992 Aug 7;70(3):431-42
Cell 1992 Aug 7;70(3):431-42
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