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- Antibody Data
- Antigen structure
- References [14]
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- Validations
- Immunohistochemistry [1]
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- Product number
- AF349 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal VEGFR3/Flt-4 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human VEGFR3/Flt-4 in direct ELISAs and Western blots. In Western blots, approximately 15% cross-reactivity with recombinant mouse VEGFR3 is observed and less than 2% cross-reactivity with recombinant human VEGFR1 is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4.
Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction.
VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling.
TGF-β1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT).
Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.
Primary Tumor-Secreted Lymphangiogenic Factors Induce Pre-Metastatic Lymphvascular Niche Formation at Sentinel Lymph Nodes in Oral Squamous Cell Carcinoma.
Expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 in esophageal squamous cell carcinoma.
VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma.
All three receptors for vascular endothelial growth factor (VEGF) are expressed on B-chronic lymphocytic leukemia (CLL) cells.
All three receptors for vascular endothelial growth factor (VEGF) are expressed on B-chronic lymphocytic leukemia (CLL) cells.
Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma.
Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma.
Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops.
Expression of vascular endothelial growth factor (VEGF)-D and its receptor, VEGF receptor 3, as a prognostic factor in endometrial carcinoma.
Volk-Draper LD, Hall KL, Wilber AC, Ran S
PloS one 2017;12(6):e0179257
PloS one 2017;12(6):e0179257
Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction.
Parry TJ, Ganguly A, Troy EL, Luis Guerrero J, Iaci JF, Srinivas M, Vecchione AM, Button DC, Hackett CS, Zolty R, Sawyer DB, Caggiano AO
European journal of pharmacology 2017 Feb 5;796:76-89
European journal of pharmacology 2017 Feb 5;796:76-89
VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling.
Heinolainen K, Karaman S, D'Amico G, Tammela T, Sormunen R, Eklund L, Alitalo K, Zarkada G
Circulation research 2017 Apr 28;120(9):1414-1425
Circulation research 2017 Apr 28;120(9):1414-1425
TGF-β1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT).
Scherer SD, Bauer J, Schmaus A, Neumaier C, Herskind C, Veldwijk MR, Wenz F, Sleeman JP
PloS one 2016;11(9):e0162221
PloS one 2016;11(9):e0162221
Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.
Takamura S, Yagi H, Hakata Y, Motozono C, McMaster SR, Masumoto T, Fujisawa M, Chikaishi T, Komeda J, Itoh J, Umemura M, Kyusai A, Tomura M, Nakayama T, Woodland DL, Kohlmeier JE, Miyazawa M
The Journal of experimental medicine 2016 Dec 12;213(13):3057-3073
The Journal of experimental medicine 2016 Dec 12;213(13):3057-3073
Primary Tumor-Secreted Lymphangiogenic Factors Induce Pre-Metastatic Lymphvascular Niche Formation at Sentinel Lymph Nodes in Oral Squamous Cell Carcinoma.
Wakisaka N, Hasegawa Y, Yoshimoto S, Miura K, Shiotani A, Yokoyama J, Sugasawa M, Moriyama-Kita M, Endo K, Yoshizaki T
PloS one 2015;10(12):e0144056
PloS one 2015;10(12):e0144056
Expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 in esophageal squamous cell carcinoma.
Omoto I, Matsumoto M, Okumura H, Uchikado Y, Setoyama T, Kita Y, Owaki T, Kijima Y, Shinchi H, Ishigami S, Ueno S, Natsugoe S
Oncology letters 2014 Apr;7(4):1027-1032
Oncology letters 2014 Apr;7(4):1027-1032
VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma.
Thelen A, Scholz A, Benckert C, von Marschall Z, Schröder M, Wiedenmann B, Neuhaus P, Rosewicz S, Jonas S
International journal of cancer 2008 Jun 1;122(11):2471-81
International journal of cancer 2008 Jun 1;122(11):2471-81
All three receptors for vascular endothelial growth factor (VEGF) are expressed on B-chronic lymphocytic leukemia (CLL) cells.
Bairey O, Boycov O, Kaganovsky E, Zimra Y, Shaklai M, Rabizadeh E
Leukemia research 2004 Mar;28(3):243-8
Leukemia research 2004 Mar;28(3):243-8
All three receptors for vascular endothelial growth factor (VEGF) are expressed on B-chronic lymphocytic leukemia (CLL) cells.
Bairey O, Boycov O, Kaganovsky E, Zimra Y, Shaklai M, Rabizadeh E
Leukemia research 2004 Mar;28(3):243-8
Leukemia research 2004 Mar;28(3):243-8
Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma.
Su JL, Shih JY, Yen ML, Jeng YM, Chang CC, Hsieh CY, Wei LH, Yang PC, Kuo ML
Cancer research 2004 Jan 15;64(2):554-64
Cancer research 2004 Jan 15;64(2):554-64
Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma.
Su JL, Shih JY, Yen ML, Jeng YM, Chang CC, Hsieh CY, Wei LH, Yang PC, Kuo ML
Cancer research 2004 Jan 15;64(2):554-64
Cancer research 2004 Jan 15;64(2):554-64
Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops.
Masood R, Kundra A, Zhu S, Xia G, Scalia P, Smith DL, Gill PS
International journal of cancer 2003 May 1;104(5):603-10
International journal of cancer 2003 May 1;104(5):603-10
Expression of vascular endothelial growth factor (VEGF)-D and its receptor, VEGF receptor 3, as a prognostic factor in endometrial carcinoma.
Yokoyama Y, Charnock-Jones DS, Licence D, Yanaihara A, Hastings JM, Holland CM, Emoto M, Sakamoto A, Sakamoto T, Maruyama H, Sato S, Mizunuma H, Smith SK
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Apr;9(4):1361-9
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Apr;9(4):1361-9
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- VEGF R3/Flt-4 in Human Cervical Squamous Metaplasia. VEGF R3/Flt-4 was detected in immersion fixed paraffin-embedded sections of human cervical squamous metaplasia using Human VEGF R3/Flt-4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF349) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
