NBP2-34654B

antibody from Novus Biologicals

Targeting: KRT8 CARD2, CK8, CYK8, K2C8, K8, KO

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

NBP2-34654B

Provider

Novus Biologicals

Product name

Mouse Monoclonal Cytokeratin 8 Antibody

Antibody type

Monoclonal

Description

Protein G purified. Epitope of this MAb is located between aa343-357. Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant) carcinoma of the breast.

Reactivity

Human, Rat

Host

Mouse

Conjugate

Biotin

Antigen sequence

Epitope of this MAb is located betw
een aa343-357.


Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark.