orb96994

antibody from Biorbyt
Targeting: ABCC4 EST170205, MOAT-B, MOATB, MRP4
Provider product page for orb96994

Antibody data

Product number
orb96994 - Provider product page
Provider
Biorbyt
Product name
ABCC4 antibody
Antibody type
Polyclonal
Description
Rabbit Polyclonal to ABCC4. ABCC4(Atp-binding cassette, subfamily c, member 4) also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene.The ABCC4 belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. By radiation hybrid analysis, Kool et al. (1997) mapped the ABCC4 gene to chromosome 13. Using FISH, Lee et al. (1998) refined the localization to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of MRP4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of MRP4 activity or knockdown of MRP4 via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. Van de Ven et al. (2008) concluded that MRP4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Storage
Store at -20°C for one year.After reconstitution, at 4°C. for one month. It can also be aliquotted and stored frozen at -20°C. for a longer time.Avoid repeated freezing and thawing.
ABCC4 protein structure - orb96994 shown in red.