NBP2-34725JF549

antibody from Novus Biologicals

Targeting: TYMS HsT422, TMS, TS, Tsase

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NBP2-34725JF549

Provider

Novus Biologicals

Product name

Mouse Monoclonal Thymidylate Synthase Antibody

Antibody type

Monoclonal

Description

Protein A purified. It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Reactivity

Human

Host

Mouse

Conjugate

Yellow dye

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark.