M00413

antibody from Boster Biological Technology
Targeting: S100A8 60B8AG, CAGA, CFAG, CGLA, MRP8, P8
Provider product page for M00413
Immunohistochemistry

Antibody data

Product number
M00413 - Provider product page
Provider
Boster Biological Technology
Product name
Anti-Macrophage L1 Protein S100A8 Monoclonal Antibody
Antibody type
Monoclonal
Description
Mouse Monoclonal Antibody [Clone SPM281] antibody for CALGRANULIN A/S100A8 detection. Host: Mouse.Size: 100ug/vial. Tested applications: IF. Reactive species: Bovine. CALGRANULIN A/S100A8 information: Molecular Weight: 10835 MW; Subcellular Localization: Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway; Tissue Specificity: Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers.
Reactivity
Human, Rat, Bovine, Canine, Goat, Guinea Pig, Porcine, Rabbit, Simian
Host
Mouse
Antibody clone number
SPM281
Vial size
100ug/vial
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
S100A8 protein structure - M00413 shown in red.