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antibody from Novus Biologicals
Targeting: TP73
P73
Western blot
Immunocytochemistry Immunoprecipitation Immunohistochemistry Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [38]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [3]
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- Product number
- NBP2-24873 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal Delta Np73 Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Image-Based Network Analysis of DNp73 Expression by Immunohistochemistry in Rectal Cancer Patients.
Splicing factor poly(rC)-binding protein 1 is a novel and distinctive tumor suppressor.
Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation.
ITGAV and ITGA5 diversely regulate proliferation and adipogenic differentiation of human adipose derived stem cells.
Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation.
TP73, an under-appreciated player in non-Hodgkin lymphoma pathogenesis and management.
Disruption of chromosomal locus 1p36 differentially modulates TAp73 and ΔNp73 expression in follicular lymphoma.
Intracellular distribution of the ΔNp73 protein isoform in medulloblastoma cells: a study with newly generated rabbit polyclonal antibodies.
TNF-α response of vascular endothelial and vascular smooth muscle cells involve differential utilization of ASK1 kinase and p73.
Site-specific risk factors for colorectal cancer in a Korean population.
IkappaB kinase beta promotes cell survival by antagonizing p53 functions through DeltaNp73alpha phosphorylation and stabilization.
ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization.
Analysis of the intracellular localization of p73 N-terminal protein isoforms TAp73 and ∆Np73 in medulloblastoma cell lines.
Interactions of the p53 protein family in cellular stress response in gastrointestinal tumors.
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway.
Evaluation of p63 and p73 antibodies for cross-reactivity.
p73 and p63 sustain cellular growth by transcriptional activation of cell cycle progression genes.
Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats.
p73 plays a role in erythroid differentiation through GATA1 induction.
STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits.
Alternate AChE-R variants facilitate cellular metabolic activity and resistance to genotoxic stress through enolase and RACK1 interactions.
Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways.
A gene signature-based approach identifies mTOR as a regulator of p73.
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.
Cooperation between p53 and p73 in cisplatin-induced apoptosis in ovarian carcinoma cells.
Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility.
Overexpressed TP73 induces apoptosis in medulloblastoma.
p73 expression in medulloblastoma: TAp73/DeltaNp73 transcript detection and possible association of p73alpha/DeltaNp73 immunoreactivity with survival.
p53 dependent and independent sensitivity to oxaliplatin of colon cancer cells.
p73 and p53 pathway in human breast cancers.
DeltaTAp73 upregulation correlates with poor prognosis in human tumors: putative in vivo network involving p73 isoforms, p53, and E2F-1.
Multiple isoforms of the tumor protein p73 are expressed in the adult human telencephalon and choroid plexus and present in the cerebrospinal fluid.
Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression.
New antibodies recognizing p73: comparison with commercial antibodies.
p73 isoforms can induce T-cell factor-dependent transcription in gastrointestinal cells.
Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells.
The p73 gene is an anti-tumoral target of the RARbeta/gamma-selective retinoid tazarotene.
DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest.
Pham TD, Fan C, Pfeifer D, Zhang H, Sun XF
Frontiers in physiology 2019;10:1551
Frontiers in physiology 2019;10:1551
Splicing factor poly(rC)-binding protein 1 is a novel and distinctive tumor suppressor.
Guo J, Jia R
Journal of cellular physiology 2018 Jan;234(1):33-41
Journal of cellular physiology 2018 Jan;234(1):33-41
Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation.
González R, De la Rosa ÁJ, Rufini A, Rodríguez-Hernández MA, Navarro-Villarán E, Marchal T, Pereira S, De la Mata M, Müller-Schilling M, Pascasio-Acevedo JM, Ferrer-Ríos MT, Gómez-Bravo MA, Padillo FJ, Muntané J
PloS one 2017;12(3):e0174326
PloS one 2017;12(3):e0174326
ITGAV and ITGA5 diversely regulate proliferation and adipogenic differentiation of human adipose derived stem cells.
Morandi EM, Verstappen R, Zwierzina ME, Geley S, Pierer G, Ploner C
Scientific reports 2016 Jul 1;6:28889
Scientific reports 2016 Jul 1;6:28889
Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation.
Prabhu VV, Hong B, Allen JE, Zhang S, Lulla AR, Dicker DT, El-Deiry WS
Cancer research 2016 Apr 1;76(7):1989-99
Cancer research 2016 Apr 1;76(7):1989-99
TP73, an under-appreciated player in non-Hodgkin lymphoma pathogenesis and management.
Hassan HM, Dave BJ, Singh RK
Current molecular medicine 2014 May;14(4):432-9
Current molecular medicine 2014 May;14(4):432-9
Disruption of chromosomal locus 1p36 differentially modulates TAp73 and ΔNp73 expression in follicular lymphoma.
Hassan HM, Varney ML, Jain S, Weisenburger DD, Singh RK, Dave BJ
Leukemia & lymphoma 2014 Dec;55(12):2924-31
Leukemia & lymphoma 2014 Dec;55(12):2924-31
Intracellular distribution of the ΔNp73 protein isoform in medulloblastoma cells: a study with newly generated rabbit polyclonal antibodies.
Veselska R, Neradil J, Nekulova M, Dobrucka L, Vojtesek B, Sterba J, Zitterbart K
Histology and histopathology 2013 Jul;28(7):913-24
Histology and histopathology 2013 Jul;28(7):913-24
TNF-α response of vascular endothelial and vascular smooth muscle cells involve differential utilization of ASK1 kinase and p73.
Rastogi S, Rizwani W, Joshi B, Kunigal S, Chellappan SP
Cell death and differentiation 2012 Feb;19(2):274-83
Cell death and differentiation 2012 Feb;19(2):274-83
Site-specific risk factors for colorectal cancer in a Korean population.
Shin A, Joo J, Bak J, Yang HR, Kim J, Park S, Nam BH
PloS one 2011;6(8):e23196
PloS one 2011;6(8):e23196
IkappaB kinase beta promotes cell survival by antagonizing p53 functions through DeltaNp73alpha phosphorylation and stabilization.
Accardi R, Scalise M, Gheit T, Hussain I, Yue J, Carreira C, Collino A, Indiveri C, Gissmann L, Sylla BS, Tommasino M
Molecular and cellular biology 2011 Jun;31(11):2210-26
Molecular and cellular biology 2011 Jun;31(11):2210-26
ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization.
Leonard MK, Kommagani R, Payal V, Mayo LD, Shamma HN, Kadakia MP
Cell death and differentiation 2011 Dec;18(12):1924-33
Cell death and differentiation 2011 Dec;18(12):1924-33
Analysis of the intracellular localization of p73 N-terminal protein isoforms TAp73 and ∆Np73 in medulloblastoma cell lines.
Nekulová M, Zitterbart K, Sterba J, Veselská R
Journal of molecular histology 2010 Oct;41(4-5):267-75
Journal of molecular histology 2010 Oct;41(4-5):267-75
Interactions of the p53 protein family in cellular stress response in gastrointestinal tumors.
Vilgelm AE, Washington MK, Wei J, Chen H, Prassolov VS, Zaika AI
Molecular cancer therapeutics 2010 Mar;9(3):693-705
Molecular cancer therapeutics 2010 Mar;9(3):693-705
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway.
Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R, Itie-Youten A, Wakeham A, Arsenian-Henriksson M, Melino G, Kaplan DR, Miller FD, Mak TW
Genes & development 2010 Mar 15;24(6):549-60
Genes & development 2010 Mar 15;24(6):549-60
Evaluation of p63 and p73 antibodies for cross-reactivity.
Rosenbluth JM, Johnson K, Tang L, Triplett T, Pietenpol JA
Cell cycle (Georgetown, Tex.) 2009 Nov 15;8(22):3702-6
Cell cycle (Georgetown, Tex.) 2009 Nov 15;8(22):3702-6
p73 and p63 sustain cellular growth by transcriptional activation of cell cycle progression genes.
Lefkimmiatis K, Caratozzolo MF, Merlo P, D'Erchia AM, Navarro B, Levrero M, Sbisa' E, Tullo A
Cancer research 2009 Nov 15;69(22):8563-71
Cancer research 2009 Nov 15;69(22):8563-71
Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats.
Sari Y, Smith KD, Ali PK, Rebec GV
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jul 22;29(29):9239-43
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jul 22;29(29):9239-43
p73 plays a role in erythroid differentiation through GATA1 induction.
Marqués-García F, Ferrandiz N, Fernández-Alonso R, González-Cano L, Herreros-Villanueva M, Rosa-Garrido M, Fernández-García B, Vaque JP, Marqués MM, Alonso ME, Segovia JC, León J, Marín MC
The Journal of biological chemistry 2009 Aug 7;284(32):21139-56
The Journal of biological chemistry 2009 Aug 7;284(32):21139-56
STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits.
Cancino GI, Toledo EM, Leal NR, Hernandez DE, Yévenes LF, Inestrosa NC, Alvarez AR
Brain : a journal of neurology 2008 Sep;131(Pt 9):2425-42
Brain : a journal of neurology 2008 Sep;131(Pt 9):2425-42
Alternate AChE-R variants facilitate cellular metabolic activity and resistance to genotoxic stress through enolase and RACK1 interactions.
Mor I, Bruck T, Greenberg D, Berson A, Schreiber L, Grisaru D, Soreq H
Chemico-biological interactions 2008 Sep 25;175(1-3):11-21
Chemico-biological interactions 2008 Sep 25;175(1-3):11-21
Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways.
Lunghi P, Giuliani N, Mazzera L, Lombardi G, Ricca M, Corradi A, Cantoni AM, Salvatore L, Riccioni R, Costanzo A, Testa U, Levrero M, Rizzoli V, Bonati A
Blood 2008 Sep 15;112(6):2450-62
Blood 2008 Sep 15;112(6):2450-62
A gene signature-based approach identifies mTOR as a regulator of p73.
Rosenbluth JM, Mays DJ, Pino MF, Tang LJ, Pietenpol JA
Molecular and cellular biology 2008 Oct;28(19):5951-64
Molecular and cellular biology 2008 Oct;28(19):5951-64
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.
Tomasini R, Tsuchihara K, Wilhelm M, Fujitani M, Rufini A, Cheung CC, Khan F, Itie-Youten A, Wakeham A, Tsao MS, Iovanna JL, Squire J, Jurisica I, Kaplan D, Melino G, Jurisicova A, Mak TW
Genes & development 2008 Oct 1;22(19):2677-91
Genes & development 2008 Oct 1;22(19):2677-91
Cooperation between p53 and p73 in cisplatin-induced apoptosis in ovarian carcinoma cells.
Righetti SC, Perego P, Carenini N, Zunino F
Cancer letters 2008 May 8;263(1):140-4
Cancer letters 2008 May 8;263(1):140-4
Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility.
Mor I, Sklan EH, Podoly E, Pick M, Kirschner M, Yogev L, Bar-Sheshet Itach S, Schreiber L, Geyer B, Mor T, Grisaru D, Soreq H
Journal of cellular and molecular medicine 2008 Apr;12(2):479-95
Journal of cellular and molecular medicine 2008 Apr;12(2):479-95
Overexpressed TP73 induces apoptosis in medulloblastoma.
Castellino RC, De Bortoli M, Lin LL, Skapura DG, Rajan JA, Adesina AM, Perlaky L, Irwin MS, Kim JY
BMC cancer 2007 Jul 12;7:127
BMC cancer 2007 Jul 12;7:127
p73 expression in medulloblastoma: TAp73/DeltaNp73 transcript detection and possible association of p73alpha/DeltaNp73 immunoreactivity with survival.
Zitterbart K, Zavrelova I, Kadlecova J, Spesna R, Kratochvilova A, Pavelka Z, Sterba J
Acta neuropathologica 2007 Dec;114(6):641-50
Acta neuropathologica 2007 Dec;114(6):641-50
p53 dependent and independent sensitivity to oxaliplatin of colon cancer cells.
Toscano F, Parmentier B, Fajoui ZE, Estornes Y, Chayvialle JA, Saurin JC, Abello J
Biochemical pharmacology 2007 Aug 1;74(3):392-406
Biochemical pharmacology 2007 Aug 1;74(3):392-406
p73 and p53 pathway in human breast cancers.
Bozzetti C, Nizzoli R, Musolino A, Martella EM, Crafa P, Lagrasta CA, Camisa R, Bonati A, Lunghi P, Ardizzoni A
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007 Apr 10;25(11):1451-3; author reply 1453-4
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007 Apr 10;25(11):1451-3; author reply 1453-4
DeltaTAp73 upregulation correlates with poor prognosis in human tumors: putative in vivo network involving p73 isoforms, p53, and E2F-1.
Domínguez G, García JM, Peña C, Silva J, García V, Martínez L, Maximiano C, Gómez ME, Rivera JA, García-Andrade C, Bonilla F
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006 Feb 10;24(5):805-15
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006 Feb 10;24(5):805-15
Multiple isoforms of the tumor protein p73 are expressed in the adult human telencephalon and choroid plexus and present in the cerebrospinal fluid.
Cabrera-Socorro A, Pueyo Morlans M, Suarez Sola ML, Gonzalez Delgado FJ, Castañeyra-Perdomo A, Marin MC, Meyer G
The European journal of neuroscience 2006 Apr;23(8):2109-18
The European journal of neuroscience 2006 Apr;23(8):2109-18
Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression.
Saifudeen Z, Diavolitsis V, Stefkova J, Dipp S, Fan H, El-Dahr SS
The Journal of biological chemistry 2005 Jun 17;280(24):23094-102
The Journal of biological chemistry 2005 Jun 17;280(24):23094-102
New antibodies recognizing p73: comparison with commercial antibodies.
Sayan AE, Paradisi A, Vojtesek B, Knight RA, Melino G, Candi E
Biochemical and biophysical research communications 2005 Apr 29;330(1):186-93
Biochemical and biophysical research communications 2005 Apr 29;330(1):186-93
p73 isoforms can induce T-cell factor-dependent transcription in gastrointestinal cells.
Tomkova K, Belkhiri A, El-Rifai W, Zaika AI
Cancer research 2004 Sep 15;64(18):6390-3
Cancer research 2004 Sep 15;64(18):6390-3
Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells.
Lunghi P, Costanzo A, Levrero M, Bonati A
Blood 2004 Jul 15;104(2):519-25
Blood 2004 Jul 15;104(2):519-25
The p73 gene is an anti-tumoral target of the RARbeta/gamma-selective retinoid tazarotene.
Papoutsaki M, Lanza M, Marinari B, Nisticò S, Moretti F, Levrero M, Chimenti S, Costanzo A
The Journal of investigative dermatology 2004 Dec;123(6):1162-8
The Journal of investigative dermatology 2004 Dec;123(6):1162-8
DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest.
Vossio S, Palescandolo E, Pediconi N, Moretti F, Balsano C, Levrero M, Costanzo A
Oncogene 2002 May 23;21(23):3796-803
Oncogene 2002 May 23;21(23):3796-803
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Delta Np73 Antibody (38C674.2) [NBP2-24873] - Delta Np73 Antibody (38C674.2) analysis for Np73 using NBP2-24873 at 1 ug/ml in A) a cell line transfected with Np73 cDNA, B) HeLa, and C) NIH 3T3 cell lysate.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Frozen: Delta Np73 Antibody (38C674.2) [NBP2-24873] - Delta Np73 Antibody (38C674.2) analysis of Delta Np73 in embryonic day 15 (A) and day 17 (B) E15 rat embryonic kidney at 1:2000. Delta Np73 is expressed in ureteric bud (UB) branches, and metanephrogenic mesenchyme (MM), as well as in cells invading the glomerular cleft. DeltaNp73 is expressed in the ureteric bud (UB) branches, metanephrogenic mesenchyme (MM), and nephron progenitors.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Delta Np73 Antibody (38C674.2) [NBP2-24873] - Delta Np73 Antibody (38C674.2) Staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Delta Np73 Antibody (38C674.2) [NBP2-24873] - Delta Np73 Antibody (38C674.2) Formalin-fixed, paraffin-embedded lung squamous cell carcinoma probed with p73 antibody at 5 ug/ml.
