A010-30AP

antibody from Badrilla Ltd
Targeting: RYR2 ARVC2, ARVD2, VTSIP
Provider product page for A010-30AP
Western blot

Antibody data

Product number
A010-30AP - Provider product page
Provider
Badrilla Ltd
Product name
RYR2 Phospho Serine-2808 (AP) IgG
Antibody type
Polyclonal
Antigen
Synthetic peptide
Description
The ryanodine receptor (RyR2) is a Ca2+ channel of cardiac muscle that plays a central role in EC coupling. The binding of Ca2+ to RyR2 opens the channel and Ca2+ stored in the SR moves through the channel into the cytosol to initiate muscle contraction. Abnormal structure and function of ryanodine receptors has been reported in failing hearts, with Ser-2808 phosphorylation appearing elevated in clinical situations which may contribute to the abnormal Ca2+ handling characteristics of cardiac muscle in these conditions. Ser-2808 can be phosphorylated in vitro by PKA or CaMKII, which is coincident with significant change in RyR2 channel function typified by an increased open probability, the abrogation of the inhibitory effects of CaM, and Mg2+, dissociation of regulatory factors, expression of subconductance states and the expression of channel activity at diastolic Ca2+ concentrations. Serine-2808 in human RyR2 equates to Ser-2809 in rabbit RyR2.
Reactivity
Human, Mouse, Rat, Canine, Rabbit
Host
Rabbit
Antigen sequence
YNRTRRIS(PO3H2)QT2810
Isotype
IgG
Vial size
100 µl
Storage
Lyophilised: 4 °C Reconstituted:-80 °C
Handling
Reconstitute lyophilised powder in 100 µl of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freeze - thaw cycles
RYR2 protein structure - A010-30AP shown in red.