A010-31AP

antibody from Badrilla Ltd
Targeting: RYR2 ARVC2, ARVD2, VTSIP
Provider product page for A010-31AP

Antibody data

Product number
A010-31AP - Provider product page
Provider
Badrilla Ltd
Product name
RYR2 Phospho Serine-2814 (AP) IgG
Antibody type
Polyclonal
Antigen
Synthetic peptide
Description
The ryanodine receptor (RyR2) is a Ca2+ channel of cardiac muscle that plays a central role in EC coupling. The binding of Ca2+ to RyR2 opens the channel and Ca2+ stored in the SR moves through the channel into the cytosol to initiate muscle contraction. CaMKII was able to phosphorylate Ser-2814 of RYR2 enhancing Ca2+- sensitivity and increasing open probability. Excessive phosphorylation of Ser-2814 leads to atrial fibrillation, arrhythmias and sudden death.
Host
Rabbit
Antigen sequence
TSQVS(PO3H2)VDAAH2819
Isotype
IgG
Vial size
100 µl
Storage
Lyophilised: 4 °C Reconstituted:-80 °C
Handling
Reconstitute lyophilised powder in 100 µl of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freeze - thaw cycles
RYR2 protein structure - A010-31AP shown in red.