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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Flow cytometry [1]
- Other assay [1]
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- Product number
- CD0330 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD3e Monoclonal Antibody (UCHT1), Pacific Orange™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Our Pacific Orange™ dye is optimally excited by the violet laser, and it is recommended that a 575, 585 or 600 nm band pass filter be used for optimal detection. Pacific Blue™ and Pacific Orange™ dye conjugates can be simultaneously excited at 405 nm and emit at 455 nm and 551 nm, respectively, facilitating two-color analysis.
- Antibody clone number
- UCHT1
Submitted references Persistence of HIV-1 Env-Specific Plasmablast Lineages in Plasma Cells after Vaccination in Humans.
A distinct plasmablast and naïve B-cell phenotype in primary immune thrombocytopenia.
Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection.
NF-κB is activated in CD4+ iNKT cells by sickle cell disease and mediates rapid induction of adenosine A2A receptors.
Expression patterns of chemokine receptors on circulating T cells from myelodysplastic syndrome patients.
Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson.
Basu M, Piepenbrink MS, Francois C, Roche F, Zheng B, Spencer DA, Hessell AJ, Fucile CF, Rosenberg AF, Bunce CA, Liesveld J, Keefer MC, Kobie JJ
Cell reports. Medicine 2020 May 19;1(2)
Cell reports. Medicine 2020 May 19;1(2)
A distinct plasmablast and naïve B-cell phenotype in primary immune thrombocytopenia.
Flint SM, Gibson A, Lucas G, Nandigam R, Taylor L, Provan D, Newland AC, Savage CO, Henderson RB
Haematologica 2016 Jun;101(6):698-706
Haematologica 2016 Jun;101(6):698-706
Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection.
Wong EB, Akilimali NA, Govender P, Sullivan ZA, Cosgrove C, Pillay M, Lewinsohn DM, Bishai WR, Walker BD, Ndung'u T, Klenerman P, Kasprowicz VO
PloS one 2013;8(12):e83474
PloS one 2013;8(12):e83474
NF-κB is activated in CD4+ iNKT cells by sickle cell disease and mediates rapid induction of adenosine A2A receptors.
Lin G, Field JJ, Yu JC, Ken R, Neuberg D, Nathan DG, Linden J
PloS one 2013;8(10):e74664
PloS one 2013;8(10):e74664
Expression patterns of chemokine receptors on circulating T cells from myelodysplastic syndrome patients.
Sand KE, Rye KP, Mannsåker B, Bruserud O, Kittang AO
Oncoimmunology 2013 Feb 1;2(2):e23138
Oncoimmunology 2013 Feb 1;2(2):e23138
Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson.
Field JJ, Lin G, Okam MM, Majerus E, Keefer J, Onyekwere O, Ross A, Campigotto F, Neuberg D, Linden J, Nathan DG
Blood 2013 Apr 25;121(17):3329-34
Blood 2013 Apr 25;121(17):3329-34
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Antigen Specificity: The UCHT1 monoclonal antibody reacts with human CD3e, a 20 kDa subunit of the TCR/CD3 complex. Along with the other CD3 subunits gamma and delta, the epsilon chain is required for proper assembly, trafficking and surface expression of the TCR complex. CD3 is expressed by developing thymocytes and by all mature T cells. Crosslinking of TCR via immobilized UCHT1 results in T cell proliferation.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
