Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- 14-9743-80 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Glucagon Monoclonal Antibody (ICACLS), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This ICACLS monoclonal antibody reacts with human, mouse, and rat glucagon. Glucagon is a peptide hormone secreted by the pancreatic alpha cells found within the islets of Langerhans. Glucagon functions as an antagonist to insulin and homeostatic regulation of blood glucose levels are maintained by the critical balance between these two hormones. Glucagon acts in the liver to convert glycogen to glucose by promoting gluconeogenesis and glycogenolysis. Secretion of glucagon is stimulated by hypoglycemia, epinephrine, acetylcholine, and cholecystokinin, while secretion is inhibited by insulin and somatostatin. Abnormally high levels of glucagon are found in pancreatic tumors.
- Antibody clone number
- ICACLS
- Concentration
- 0.5 mg/mL
Submitted references Pregestational diet transition to normal-fat diet avoids the deterioration of pancreatic β-cell function in male offspring induced by maternal high-fat diet.
The physiology of glucagon.
Glucagon as a target for the treatment of Type 2 diabetes.
Glucagon and regulation of glucose metabolism.
Liu Z, Ding Z, Lynch EC, McCauley N, Zhou Y, Zhang KK, Xie L
The Journal of nutritional biochemistry 2020 Dec;86:108495
The Journal of nutritional biochemistry 2020 Dec;86:108495
The physiology of glucagon.
Taborsky GJ Jr
Journal of diabetes science and technology 2010 Nov 1;4(6):1338-44
Journal of diabetes science and technology 2010 Nov 1;4(6):1338-44
Glucagon as a target for the treatment of Type 2 diabetes.
Sloop KW, Michael MD, Moyers JS
Expert opinion on therapeutic targets 2005 Jun;9(3):593-600
Expert opinion on therapeutic targets 2005 Jun;9(3):593-600
Glucagon and regulation of glucose metabolism.
Jiang G, Zhang BB
American journal of physiology. Endocrinology and metabolism 2003 Apr;284(4):E671-8
American journal of physiology. Endocrinology and metabolism 2003 Apr;284(4):E671-8
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Immunohistochemistry of formalin-fixed paraffin embedded human pancreas using 0.1 µg/mL of Anti-Glucagon Purified, followed by Anti-Mouse IgG Biotin, Streptavidin HRP and DAB visualization.Nuclei are counterstained with hematoxylin.