NBP2-47773AF405

antibody from Novus Biologicals

Targeting: NKX2-1 BCH, NKX2A, TITF1, TTF-1, TTF1

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NBP2-47773AF405

Provider

Novus Biologicals

Product name

Mouse Monoclonal TTF-1 / NKX2-1 Antibody

Antibody type

Monoclonal

Description

Protein A or G purified. Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Blue dye

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark.