NBP2-47931JF549

antibody from Novus Biologicals
Targeting: WT1 AWT1, GUD, NPHS4, WAGR, WIT-2
Provider product page for NBP2-47931JF549
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
NBP2-47931JF549 - Provider product page
Provider
Novus Biologicals
Product name
Mouse Monoclonal WT1 Antibody
Antibody type
Monoclonal
Description
Protein A or G purified. Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm s tumors.WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas.
Reactivity
Human, Mouse, Rat
Host
Mouse
Conjugate
Yellow dye
Isotype
IgG
Vial size
0.1 ml
Storage
Store at 4C in the dark.
WT1 protein structure - NBP2-47931JF549 shown in red.