orb48102

antibody from Biorbyt
Targeting: AIFM1 AIF, AUNX1, CMTX4, DFNX5, NAMSD, PDCD8
Provider product page for orb48102

Antibody data

Product number
orb48102 - Provider product page
Provider
Biorbyt
Product name
Anti-AIF antibody
Antibody type
Monoclonal
Description
Mouse monoclonal to AIF. A key event in the apoptotic process is the opening of the mitochondrial permeability transition pore, an event that is regulated by Bcl-2 family proteins, resulting in the release of several proteins from the mitochondrial intermembrane space. Several of these proteins participate in apoptosis, including cytochrome c, procaspases 2, 3, and 9 and AIF (apoptosis-inducing factor). AIF was shown to cause DNA fragmentation and chromatin condensation, and to induce the release of cytochrome c and caspase-9 from mitochondria. Bcl-2 overexpression was shown to prevent the release of AIF from mitochondria, but not to block its apoptogenic activity.
Reactivity
Human, Mouse, Rat
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
44C6
Vial size
100 μg
Storage
At -20°C for one year. After reconstitution, at 4°C for two weeks. It can also be aliquotted and stored frozen at -20°C for a longer time.
AIFM1 protein structure - orb48102 shown in red.