Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- orb48102 - Provider product page
- Provider
- Biorbyt
- Product name
- Anti-AIF antibody
- Antibody type
- Monoclonal
- Description
- Mouse monoclonal to AIF. A key event in the apoptotic process is the opening of the mitochondrial permeability transition pore, an event that is regulated by Bcl-2 family proteins, resulting in the release of several proteins from the mitochondrial intermembrane space. Several of these proteins participate in apoptosis, including cytochrome c, procaspases 2, 3, and 9 and AIF (apoptosis-inducing factor). AIF was shown to cause DNA fragmentation and chromatin condensation, and to induce the release of cytochrome c and caspase-9 from mitochondria. Bcl-2 overexpression was shown to prevent the release of AIF from mitochondria, but not to block its apoptogenic activity.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- 44C6
- Vial size
- 100 μg
- Storage
- At -20°C for one year. After reconstitution, at 4°C for two weeks. It can also be aliquotted and stored frozen at -20°C for a longer time.
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Supportive validation
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- Biorbyt (provider)
- Main image
- Experimental details
- Western blot analysis of hela,293T,MCF7,COS7,NIH/3T3,PC12,CHO-K1,MDCK whole cell line lysates using AIF antibody