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Learn9246
antibody from Cell Signaling Technology, Inc
Targeting: NFKBIA
IkappaBalpha, IKBA, MAD-3, NFKBI
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations [0]
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- Product number
- 9246 - Provider product page
- Provider
- Cell Signaling Technology, Inc
- Proper citation
- Cell Signaling Technology Cat#9246, RRID:AB_2267145
- Product name
- Phospho-IκBα (Ser32/36) (5A5) Mouse mAb
- Antibody type
- Monoclonal
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Mouse
- Storage
- -20°C
Submitted references p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO.
Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation.
The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation.
A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice.
Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.
Tumor-associated a2 vacuolar ATPase acts as a key mediator of cancer-related inflammation by inducing pro-tumorigenic properties in monocytes.
Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.
Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts.
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.
TLR3 ligand induces NF-{kappa}B activation and various fates of multiple myeloma cells depending on IFN-{alpha} production.
Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.
IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver.
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.
Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms.
Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.
A fourth IkappaB protein within the NF-kappaB signaling module.
B cell lymphoma 10 is essential for FcepsilonR-mediated degranulation and IL-6 production in mast cells.
Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons.
Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways.
NF-kappaB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix.
Oxidative modulation of nuclear factor-kappaB in human cells expressing mutant fALS-typical superoxide dismutases.
Participation of the calcium/calmodulin-dependent kinases in hydrogen peroxide-induced Ikappa B phosphorylation in human T lymphocytes.
Shibata Y, Oyama M, Kozuka-Hata H, Han X, Tanaka Y, Gohda J, Inoue J
Nature communications 2012;3:1061
Nature communications 2012;3:1061
Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation.
Tokunaga F, Nishimasu H, Ishitani R, Goto E, Noguchi T, Mio K, Kamei K, Ma A, Iwai K, Nureki O
The EMBO journal 2012 Oct 3;31(19):3856-70
The EMBO journal 2012 Oct 3;31(19):3856-70
The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation.
Gardner A, Fisher AJ, Richter C, Johnson GE, Moisey EJ, Brodlie M, Ward C, Krippner-Heidenreich A, Mann DA, Borthwick LA
The American journal of pathology 2012 Jun;180(6):2293-308
The American journal of pathology 2012 Jun;180(6):2293-308
A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice.
Wehenkel M, Ban JO, Ho YK, Carmony KC, Hong JT, Kim KB
British journal of cancer 2012 Jun 26;107(1):53-62
British journal of cancer 2012 Jun 26;107(1):53-62
Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.
Kensche T, Tokunaga F, Ikeda F, Goto E, Iwai K, Dikic I
The Journal of biological chemistry 2012 Jul 6;287(28):23626-34
The Journal of biological chemistry 2012 Jul 6;287(28):23626-34
Tumor-associated a2 vacuolar ATPase acts as a key mediator of cancer-related inflammation by inducing pro-tumorigenic properties in monocytes.
Kwong C, Gilman-Sachs A, Beaman K
Journal of immunology (Baltimore, Md. : 1950) 2011 Feb 1;186(3):1781-9
Journal of immunology (Baltimore, Md. : 1950) 2011 Feb 1;186(3):1781-9
Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.
Mabilleau G, Sabokbar A
PloS one 2009;4(1):e4173
PloS one 2009;4(1):e4173
Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts.
Turner NA, Das A, Warburton P, O'Regan DJ, Ball SG, Porter KE
American journal of physiology. Heart and circulatory physiology 2009 Sep;297(3):H1117-27
American journal of physiology. Heart and circulatory physiology 2009 Sep;297(3):H1117-27
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.
Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S, Takao T, Tanaka K, Iwai K
Nature cell biology 2009 Feb;11(2):123-32
Nature cell biology 2009 Feb;11(2):123-32
TLR3 ligand induces NF-{kappa}B activation and various fates of multiple myeloma cells depending on IFN-{alpha} production.
Chiron D, Pellat-Deceunynck C, Amiot M, Bataille R, Jego G
Journal of immunology (Baltimore, Md. : 1950) 2009 Apr 1;182(7):4471-8
Journal of immunology (Baltimore, Md. : 1950) 2009 Apr 1;182(7):4471-8
Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.
Saitoh Y, Yamamoto N, Dewan MZ, Sugimoto H, Martinez Bruyn VJ, Iwasaki Y, Matsubara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, Masuda T, Yamamoto N, Yamaoka S
Blood 2008 May 15;111(10):5118-29
Blood 2008 May 15;111(10):5118-29
IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver.
Luedde T, Heinrichsdorff J, de Lorenzi R, De Vos R, Roskams T, Pasparakis M
Proceedings of the National Academy of Sciences of the United States of America 2008 Jul 15;105(28):9733-8
Proceedings of the National Academy of Sciences of the United States of America 2008 Jul 15;105(28):9733-8
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.
Vince JE, Chau D, Callus B, Wong WW, Hawkins CJ, Schneider P, McKinlay M, Benetatos CA, Condon SM, Chunduru SK, Yeoh G, Brink R, Vaux DL, Silke J
The Journal of cell biology 2008 Jul 14;182(1):171-84
The Journal of cell biology 2008 Jul 14;182(1):171-84
Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms.
Lou H, Kaplowitz N
The Journal of biological chemistry 2007 Oct 5;282(40):29470-81
The Journal of biological chemistry 2007 Oct 5;282(40):29470-81
Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.
Wright A, Reiley WW, Chang M, Jin W, Lee AJ, Zhang M, Sun SC
Developmental cell 2007 Nov;13(5):705-16
Developmental cell 2007 Nov;13(5):705-16
A fourth IkappaB protein within the NF-kappaB signaling module.
Basak S, Kim H, Kearns JD, Tergaonkar V, O'Dea E, Werner SL, Benedict CA, Ware CF, Ghosh G, Verma IM, Hoffmann A
Cell 2007 Jan 26;128(2):369-81
Cell 2007 Jan 26;128(2):369-81
B cell lymphoma 10 is essential for FcepsilonR-mediated degranulation and IL-6 production in mast cells.
Chen Y, Pappu BP, Zeng H, Xue L, Morris SW, Lin X, Wen R, Wang D
Journal of immunology (Baltimore, Md. : 1950) 2007 Jan 1;178(1):49-57
Journal of immunology (Baltimore, Md. : 1950) 2007 Jan 1;178(1):49-57
Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons.
Schultz C, König HG, Del Turco D, Politi C, Eckert GP, Ghebremedhin E, Prehn JH, Kögel D, Deller T
Molecular and cellular neurosciences 2006 Sep;33(1):68-80
Molecular and cellular neurosciences 2006 Sep;33(1):68-80
Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways.
Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G
Molecular cell 2004 May 7;14(3):303-17
Molecular cell 2004 May 7;14(3):303-17
NF-kappaB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix.
Nair A, Venkatraman M, Maliekal TT, Nair B, Karunagaran D
Oncogene 2003 Jan 9;22(1):50-8
Oncogene 2003 Jan 9;22(1):50-8
Oxidative modulation of nuclear factor-kappaB in human cells expressing mutant fALS-typical superoxide dismutases.
Casciati A, Ferri A, Cozzolino M, Celsi F, Nencini M, Rotilio G, Carrì MT
Journal of neurochemistry 2002 Dec;83(5):1019-29
Journal of neurochemistry 2002 Dec;83(5):1019-29
Participation of the calcium/calmodulin-dependent kinases in hydrogen peroxide-induced Ikappa B phosphorylation in human T lymphocytes.
Howe CJ, LaHair MM, Maxwell JA, Lee JT, Robinson PJ, Rodriguez-Mora O, McCubrey JA, Franklin RA
The Journal of biological chemistry 2002 Aug 23;277(34):30469-76
The Journal of biological chemistry 2002 Aug 23;277(34):30469-76
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