ABIN966560

antibody from antibodies-online

Targeting: MAP2K1 MAPKK1, MEK1, PRKMK1

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN966560

Provider

antibodies-online

Product name

anti-Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) (pSer221) antibody

Antibody type

Polyclonal

Antigen

The antiserum was produced against synthesized phosphopeptide derived from human MEK1 around the phosphorylation site of serine 221 (A-N-SP-F-V).

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

pSer221

Vial size

100 μg

Concentration

100ug/100ul.

Storage

-20°C

References

Submitted references

Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia.

Zebisch A, Staber PB, Delavar A, Bodner C, Hiden K, Fischereder K, Janakiraman M, Linkesch W, Auner HW, Emberger W, Windpassinger C, Schimek MG, Hoefler G, Troppmair J, Sill H
Cancer research 2006 Apr 1;66(7):3401-8

---

Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.

Luciano BS, Hsu S, Channavajhala PL, Lin LL, Cuozzo JW
The Journal of biological chemistry 2004 Dec 10;279(50):52117-23

---

Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1.

Gopalbhai K, Jansen G, Beauregard G, Whiteway M, Dumas F, Wu C, Meloche S
The Journal of biological chemistry 2003 Mar 7;278(10):8118-25

---

MAD2-induced sensitization to vincristine is associated with mitotic arrest and Raf/Bcl-2 phosphorylation in nasopharyngeal carcinoma cells.

Wang X, Jin DY, Wong HL, Feng H, Wong YC, Tsao SW
Oncogene 2003 Jan 9;22(1):109-16