ABIN197397

antibody from antibodies-online

Targeting: RPS6KB1 p70(S6K)-alpha, PS6K, S6K, S6K1, STK14A

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

ABIN197397

Provider

antibodies-online

Product name

anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1) (Thr389) antibody

Antibody type

Polyclonal

Description

Immunoaffinity Chromatography using epitope-specific immunogen.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

Thr389

Vial size

50 μL

Storage

Store the antibody (in aliquots) at -20°C.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis.

Le XF, Hittelman WN, Liu J, McWatters A, Li C, Mills GB, Bast RC Jr
Oncogene 2003 Jan 30;22(4):484-97

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Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes.

Krause U, Bertrand L, Hue L
European journal of biochemistry 2002 Aug;269(15):3751-9

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Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt.

Eguchi S, Iwasaki H, Ueno H, Frank GD, Motley ED, Eguchi K, Marumo F, Hirata Y, Inagami T
The Journal of biological chemistry 1999 Dec 24;274(52):36843-51

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Cdc2-cyclin B phosphorylates p70 S6 kinase on Ser411 at mitosis.

Papst PJ, Sugiyama H, Nagasawa M, Lucas JJ, Maller JL, Terada N
The Journal of biological chemistry 1998 Jun 12;273(24):15077-84