BS7638

antibody from Bioworld Technology, Inc
Targeting: EIF2AK2 EIF2AK1, PKR, PPP1R83, PRKR
Provider product page for BS7638
Western blot
Immunohistochemistry

Antibody data

Product number
BS7638 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Eif2ak2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human Eif2ak2.
Description
Interferon-inducible RNA-dependent protein serine/threonine kinase, PKR, is variously designated in earlier literature as DAI, dsJ, PI kinase, p65, p67 or TIK for the mouse kinase; and p68 or p69 for the human kinase. The PKR kinase substrate is the a subunit of protein synthesis initiation factor eIF-2. Phosphorylation of eIF-2a on serine-51 results in inhibition of translation. Molecular cDNA clones have been isolated from both human and mouse cells. The serine/threonine kinase catalytic domains map to the carboxy terminal half of the protein while the RNA-binding domains are located in the amino terminal region. Three kinds of regulation of PKR enzymatic activity have been described. These include transcriptional regulation in response to interferon, an autoregulatory mechanism controlling PKR expression at the level of translation and post-translational regulation by RNA-mediated autophosphorylation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
EIF2AK2 protein structure - BS7638 shown in red.