NBP2-47927B

antibody from Novus Biologicals

Targeting: TGM2 TGC

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

NBP2-47927B

Provider

Novus Biologicals

Product name

Mouse Monoclonal Transglutaminase 2/TGM2 Antibody

Antibody type

Monoclonal

Description

Protein A or G purified. Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.

Reactivity

Human, Mouse, Rat, Rabbit, Simian

Host

Mouse

Conjugate

Biotin

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark.