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- Antibody Data
- Antigen structure
- References [4]
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- Product number
- 12-0667-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD66c Monoclonal Antibody (KOR-SA3544), PE, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This KOR-SA3544 monoclonal antibody reacts with human CD66c (also known as CEACAM6), which is one of the splice variants of CD66. CD66c is expressed on endothelial and epithelial cells, as well as on neutrophils and monocytes. Myeloma and cancer cells, such as B-cell acute lymphoblastic lymphomas, also express CD66c. Moreover, expression of this receptor can be induced on T cells, B cells, and CD16-negative NK cells. Like the other CD66 splice variants, CD66c is involved in cell adhesion and growth, neutrophil activation, and signaling. Moreover, expression of CD66c in leukemic cells has been correlated with BCR/ABL1 rearrangement. Finally, studies have shown that the CD66 variants interact with each other homo- and heterotypically.
- Conjugate
- Yellow dye
- Antibody clone number
- KOR-SA3544
- Concentration
- 5 µL/Test
Submitted references Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells.
CEACAMs: their role in physiology and pathophysiology.
Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens.
The KOR-SA3544 antigen predominantly expressed on the surface of Philadelphia chromosome-positive acute lymphoblastic leukemia cells is nonspecific cross-reacting antigen-50/90 (CD66c) and invariably expressed in cytoplasm of human leukemia cells.
Skubitz KM, Skubitz AP
Journal of translational medicine 2008 Dec 10;6:78
Journal of translational medicine 2008 Dec 10;6:78
CEACAMs: their role in physiology and pathophysiology.
Kuespert K, Pils S, Hauck CR
Current opinion in cell biology 2006 Oct;18(5):565-71
Current opinion in cell biology 2006 Oct;18(5):565-71
Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens.
Kalina T, Vaskova M, Mejstrikova E, Madzo J, Trka J, Stary J, Hrusak O
BMC cancer 2005 Apr 12;5:38
BMC cancer 2005 Apr 12;5:38
The KOR-SA3544 antigen predominantly expressed on the surface of Philadelphia chromosome-positive acute lymphoblastic leukemia cells is nonspecific cross-reacting antigen-50/90 (CD66c) and invariably expressed in cytoplasm of human leukemia cells.
Sugita K, Mori T, Yokota S, Kuroki M, Koyama TO, Inukai T, Iijima K, Goi K, Tezuka T, Kojika S, Shiraishi K, Nakamura M, Miyamoto N, Karakida N, Kagami K, Nakazawa S
Leukemia 1999 May;13(5):779-85
Leukemia 1999 May;13(5):779-85
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Anti-Human CD66 APC (Product # 17-0668-42) and Mouse IgG1 K Isotype Control PE (Product # 12-4714-81) (left) or Anti-Human CD66c (right). Cells in the granulocyte gate were used for analysis.
- Conjugate
- Yellow dye
