NBP2-33160JF646

antibody from Novus Biologicals

Targeting: TYR OCA1, OCA1A, OCAIA

ELISA (Data presented on provider website)

Antibody Data

Product number

NBP2-33160JF646

Provider

Novus Biologicals

Product name

Mouse Monoclonal Tyrosinase Antibody

Antibody type

Monoclonal

Description

Protein G purified. Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.

Reactivity

Human

Host

Mouse

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark.