NBP2-47689UV

antibody from Novus Biologicals

Targeting: TAGLN DKFZp686P11128, SM22, SMCC, TAGLN1, WS3-10

Immunohistochemistry (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NBP2-47689UV

Provider

Novus Biologicals

Product name

Mouse Monoclonal Transgelin/TAGLN/SM22 alpha Antibody

Antibody type

Monoclonal

Description

Protein A or G purified. This MAb recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.

Reactivity

Human, Mouse, Porcine, Rabbit, Simian

Host

Mouse

Conjugate

Blue dye

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark.