NB100-65388APCCY7

antibody from Novus Biologicals

Targeting: SELL CD62L, hLHRc, LAM-1, LAM1, Leu-8, LNHR, LSEL, Lyam-1, LYAM1, PLNHR

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NB100-65388APCCY7

Provider

Novus Biologicals

Product name

Mouse Monoclonal L-Selectin/CD62L Antibody

Antibody type

Monoclonal

Description

Protein G purified. NB100-65388 recognizes human CD62L, also known a L-selectin, a 74-95kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naive lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.

Reactivity

Human, Bovine, Canine, Simian

Host

Mouse

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark. Do not freeze.