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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Immunohistochemistry [1]
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- Product number
- PAB16958 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB16958, RRID:AB_10615934
- Product name
- TSC2 (phospho S1254) polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of TSC2.
- Storage
- Store at 4°C for three months. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, Guo R, Johnson CL, Kiguchi K, Walker CL
The Journal of cell biology 2006 Apr 24;173(2):279-89
The Journal of cell biology 2006 Apr 24;173(2):279-89
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J
Proceedings of the National Academy of Sciences of the United States of America 2004 Sep 14;101(37):13489-94
Proceedings of the National Academy of Sciences of the United States of America 2004 Sep 14;101(37):13489-94
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
Li Y, Inoki K, Vacratsis P, Guan KL
The Journal of biological chemistry 2003 Apr 18;278(16):13663-71
The Journal of biological chemistry 2003 Apr 18;278(16):13663-71
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Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of paraffin-embedded human prostate carcinoma tissue using TSC2 (phospho Ser1254) polyclonal antibody (Cat # PAB16958).
- Validation comment
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
