NBP2-47929AF700

antibody from Novus Biologicals

Targeting: CD22 SIGLEC-2, SIGLEC2

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NBP2-47929AF700

Provider

Novus Biologicals

Product name

Mouse Monoclonal Siglec-2/CD22 Antibody

Antibody type

Monoclonal

Description

Protein A or G purified. Recognizes a protein of 130-140kDa, identified as CD22 (also known as BL-CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.

Reactivity

Human

Host

Mouse

Conjugate

Near infrared dye

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark.