12-0229-42

antibody from Invitrogen Antibodies
Targeting: CD22 SIGLEC-2, SIGLEC2
Provider product page for 12-0229-42

Antibody data

Product number
12-0229-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD22 Monoclonal Antibody (eBio4KB128 (4KB128)), PE, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The eBio4KB128 monoclonal antibody recognizes human CD22 (Siglec-2), which is a member of the siglec subgroup of the Ig superfamily. CD22 is a type I transmembrane glycoprotein composed of two polypeptide chains, CD22alpha and CD22beta, of 130 and 140 kDa respectively, produced by alternative splicing of the CD22 gene. CD22 is expressed at high levels on mature B cells and B cell lymphomas. The extracellular portion of CD22 contains seven Ig-like domains, some of which are capable of binding ligands with sialic acid moieties expressed on epithelial, endothelial, B and T cells. The intracellular portion of CD22 contains 6 tyrosine residues contained within immunotyrosine-based inhibitory motifs (ITIM) and immunotyrosine-based activation-like motifs, which are phosphorylated upon B-cell receptor engagement, which enables CD22 to participate in the positive and negative regulation of B-cell receptor signaling.
Conjugate
Yellow dye
Antibody clone number
eBio4KB128 (4KB128)
Concentration
5 µL/Test
CD22 protein structure - 12-0229-42 shown in red.