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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Validations
- Immunohistochemistry [1]
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- Product number
- 14-0256-80 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD25 Monoclonal Antibody (GLLZDMY), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This GLLZDMY monoclonal antibody reacts with human CD25, which is also known as the low-affinity interleukin (IL)-2 receptor alpha. CD25 is expressed on activated T cells (including a subset of regulatory T cells), B cells, and macrophages. This receptor subunit associates with CD122, the IL-2 receptor beta chain, and CD132, the common gamma chain, to form the high-affinity IL-2 receptor. IL-2 receptor signaling has been linked to cell proliferation and survival in lymphocytes. CD25 is a marker for Hodgkin's disease, and has been associated with such autoimmune diseases such as Type I diabetes.
- Antibody clone number
- GLLZDMY
- Concentration
- 0.5 mg/mL
Submitted references IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity.
Immunotoxins constructed with anti-CD25 monoclonal antibodies and deglycosylated ricin A-chain have potent anti-tumour effects against human Hodgkin cells in vitro and solid Hodgkin tumours in mice.
Wang J, Wicker LS, Santamaria P
Seminars in immunology 2009 Dec;21(6):363-71
Seminars in immunology 2009 Dec;21(6):363-71
Immunotoxins constructed with anti-CD25 monoclonal antibodies and deglycosylated ricin A-chain have potent anti-tumour effects against human Hodgkin cells in vitro and solid Hodgkin tumours in mice.
Engert A, Martin G, Amlot P, Wijdenes J, Diehl V, Thorpe P
International journal of cancer 1991 Sep 30;49(3):450-6
International journal of cancer 1991 Sep 30;49(3):450-6
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- Invitrogen Antibodies (provider)
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- Experimental details
- Immunohistochemistry of formalin-fixed paraffin embedded human tonsil using 5 µg/mL of Anti-Human CD25 Purified, followed by Anti-Mouse IgG Biotin, Streptavidin HRP and DAB visualization. Nuclei are counterstained with hematoxylin.
