BS4444

antibody from Bioworld Technology, Inc
Targeting: PPARG NR1C3, PPARG1, PPARG2, PPARgamma
Provider product page for BS4444
Western blot
Immunohistochemistry

Antibody data

Product number
BS4444 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PPARÎÛ (phospho S112) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human PPARÎÛ around the phosphorylation site of Serine 112.
Description
PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PPARG protein structure - BS4444 shown in red.