Antibody data

Product number
BS60922 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL4R polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human IL4R.
Description
The IL-2 receptor is a multicomponent complex consisting of three subunits,Ï«, ÉÇ and ÎÛ, each of which is required for high affinity binding of IL-2. The Ï« chain functions primarily in binding IL-2, whereas the ÉÇ and ÎÛ chains contribute to IL-2 binding and are essential to IL-2-induced activation of signaling pathways leading to T cell growth. Both IL-4R and IL-7R were initially described as single chain, high-affinity ligand-binding cytokine receptors. However, it is now well established that the IL-2RÎÛ chain functions as a second subunit of the high affinity IL-4R and IL-7R receptors. Consequently, the originally described subunits of these latter receptors are now referred to as IL-4RÏ« and IL-7RÏ«, respectively, while the common subunit is referred to as ÎÛc. Although the common ÎÛ chain enhances ligand binding in these three cytokine receptors, it has no capacity to bind these ligands on its own. There is evidence that the ÎÛc chain is also a subunit of IL-13R.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IL4R protein structure - BS60922 shown in red.