orb137134

antibody from Biorbyt
Targeting: KITLG DFNA69, FPH2, Kitl, KL-1, MGF, SCF, SF, SLF
Provider product page for orb137134

Antibody data

Product number
orb137134 - Provider product page
Provider
Biorbyt
Product name
SCF antibody
Antibody type
Polyclonal
Description
Rabbit polyclonal to SCF. Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Isotype
IgG
Vial size
20 μl, 50 μl, 100 μl
Concentration
1 mg/ml
KITLG protein structure - orb137134 shown in red.