orb151306

antibody from Biorbyt

Targeting: HSPA5 BiP, GRP78

Western blot (Recommended by provider)

Antibody Data

Product number

orb151306

Provider

Biorbyt

Product name

GRP78 antibody (ATTO-700)

Antibody type

Polyclonal

Description

Rabbit polyclonal to GRP78 (ATTO-700). GRP78 is a ubiquitously expressed, 78-kDa glucose regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' non-translated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed. GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis. Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival. In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress, and its protein levels are reduced in the brains of Alzheimers patients. Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs ..

Reactivity

Human, Mouse, Rat, Bovine, Hamster, Simian, Xenopus

Host

Rabbit

Conjugate

Near infrared dye

Vial size

200 μl

Storage

Store at 2-8°C and -20°C for one year. (Shipped on ice packs)