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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Product number
- ABIN362278 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Insulin Receptor Substrate 1 (IRS1) (pSer636) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around phosphorylation site of pSer636 (P-M-S (p) -P-K) derived from Human IRS-1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- pSer636
- Isotype
- IgG
- Vial size
- 100 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
Selective interaction between leptin and insulin signaling pathways in a hepatic cell line.
Insights into insulin resistance and type 2 diabetes from knockout mouse models.
Tzatsos A, Kandror KV
Molecular and cellular biology 2006 Jan;26(1):63-76
Molecular and cellular biology 2006 Jan;26(1):63-76
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB
Proceedings of the National Academy of Sciences of the United States of America 2001 Apr 10;98(8):4640-5
Proceedings of the National Academy of Sciences of the United States of America 2001 Apr 10;98(8):4640-5
Selective interaction between leptin and insulin signaling pathways in a hepatic cell line.
Szanto I, Kahn CR
Proceedings of the National Academy of Sciences of the United States of America 2000 Feb 29;97(5):2355-60
Proceedings of the National Academy of Sciences of the United States of America 2000 Feb 29;97(5):2355-60
Insights into insulin resistance and type 2 diabetes from knockout mouse models.
Kadowaki T
The Journal of clinical investigation 2000 Aug;106(4):459-65
The Journal of clinical investigation 2000 Aug;106(4):459-65
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