Antibody data

Product number
10-3012-F - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-MyD88 Antibody
Antibody type
Monoclonal
Description
MyD88 (Myeloid differentiation factor) is an essential adaptor molecule in all TLR (Toll-like receptor) signaling pathways except TLR3. MyD88 is composed of an N-terminal (Death Domain) and a highly conserved C-terminal TIR (Toll/interleukin-1 Receptor) domain. It is found to stimulate IL-1R/IL18R-mediated signaling. MyD88-dependent signaling is also important in the regulation of innate as well as acquired immunity, in particular, T-cell responses, to various microbial pathogens. After activation of TLRs, MyD88 is phosphorylated and subsequently recruits IRAKs (IL-1R Associated Kinases) and other downstream proteins such as TRAF6, finally resulting in activation of the NF-kappaB (nuclear factor kappa B) pathway.
Reactivity
Human
Host
Mouse
Conjugate
Green dye
Antigen sequence
A partial length recombinant protei
n of human MyD88 (amino acids 13-22
1) was used as an immunogen for thi
s antibody.
Isotype
IgG
Antibody clone number
ABM2H20
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
MYD88 protein structure - 10-3012-F shown in red.